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Sialolithiasis is a multi-factorial pathology that accounts for more than 50% of salivary gland disease. However, the exact impact of salivary pH and calcium (Ca2+) and phosphate (PO4 3-) on the sialoliths' formation still remains unknown. Materials and Methods: Seven removed sialoliths were put into flasks with artificial saliva solution that differed in concentrations of Ca2+ and PO4 3-. The changes in weights of sialoliths and alterations in pH had been measured for 13 weeks. Concentrations of Ca2+ and PO4 3- in the artificial saliva solution were estimated at the beginning and at the end of the experiment. Results: Sialoliths' weight decrease was observed from the 2nd to 7th week. It occurred parallel with natural pH decrease (from 7 to 6.5 pH). Sialoliths' weights started increasing after pH was adjusted with NaOH. Analyzing the concentration changes of Ca2+ in every flask, it was determined that from natural or double Ca2+ concentration, it decreased till similar amount (7-14 times). Analyzing the concentration changes of PO4 3-, it was determined that from natural or double PO4 3- concentration it decreased 24 times. Conclusions: Sialoliths' weights decreased parallel with natural pH decrease and sialoliths grew when pH was adjusted. PO4 3- ions concentration decreased relatively more than Ca2+ ions concentration. [ABSTRACT FROM AUTHOR]