Search

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the latest therapeutic strategy in the treatment of type 2 diabetes mellitus (T2DM). Using an insulin-independent mechanism (glycosuria), they reduce glucose toxicity and improve insulin sensitivity and β-cell function. The promising results obtained in clinical trials show that SGLT2 significantly improves glycemic control and provides greater cardiovascular protection, combined with a reduction in body weight and blood pressure (BP). This review focuses on ertugliflozin, a new, highly selective, and reversible SGLT2 inhibitor. Clinical trials published to date show that ertugliflozin, both as a monotherapy and as an add-on to oral antidiabetic agents, is safe and effective in reducing glycosylated hemoglobin (HbA1c), body weight, and BP in T2DM patients., Competing Interests: Disclosure AG has received consultancy fees from Boehringer Ingelheim, MSD, Sanofi, Eli Lilly, Takeda, and Astra Zeneca. The sponsors were not directly involved in the design and conduct of the paper, the collection, management, analysis, and interpretation of the data, or the preparation, review, or approval of the manuscript. The authors report no other conflicts of interest in this work.