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Purpose: For patients with psoriasis, treatment adherence and persistence are fundamental if therapeutic goals are to be met. Patient Support Programs (PSPs) may be used as a support tool to assist patients and health care professionals optimize treatment and improve disease management., Patients and Methods: In Italy, the PSP PSOLife CARE, which began on the 9th of February 2017 and is ongoing, aimed to support patients with psoriasis under therapy with secukinumab (Cosentyx ® ). A team of medical professionals including Dermatologists, Psychologists, Nutritionists, and field Nurses provided outpatient treatment as well as remote support via phone calls. Patients had a standard duration in the Program of 6 months. This report analyzes the data of patients who benefited from the Program from February 2017 to August 2020, for a total observation of 42 months., Results: We provide here a descriptive report on the benefits of participation in the PSOLife CARE Program for patients with psoriasis and medical professionals involved in their care. Throughout their time in the PSOLife CARE Program, patient satisfaction remained consistently high with sustained improvements observed in all aspects of quality of life (ie emotional, social, physical, and economic). Despite exiting from the Program, most patients continued to adhere to secukinumab. Medical professionals also reported positive outcomes on their interactions with patients, with more than half of those surveyed rating the overall quality of the Program as "Outstanding"., Conclusion: By supporting treatment adherence, the PSOLife CARE Program may have empowered patients to better manage their psoriasis, increasing their satisfaction with treatment and quality of life., Competing Interests: Giuseppe Argenziano has no conflict of interest to declare. Paolo Amerio has served as a consultant or Speaker for Abbvie, Celgene, Pfizer, Sanofi-Genzyme, Eli Lilly, and Jannsen, Galderma. Maria Grazia Aragone has served on advisory boards for Novartis, AbbVie, LeoPharma. Ginevra Baggini has no conflict of interest to declare. Manuela Baldari has no conflict of interest to declare. Gianpiero Castelli has no conflict of interest to declare. Simmaco Coppola is IQVIA employee. Antonio Costanzo has served as an advisory board member and consultant, and has received fees and speaker’s honoraria or has participated in clinical trials for Abbvie, Almirall, Biogen, LEO Pharma, Lilly, Janssen, Novartis, Pfizer, Sanofi Genzyme, and UCB-Pharma. De Pasquale has no conflict of interest to declare. Maria Concetta Fargnoli has served on advisory boards, received honoraria for lectures and research grants from Mylan, Medac Pharma, Pierre Fabre, Sanofi-Genzyme, Sunpharma, MSD. Caterina Foti advisory board and speaker for Novartis, Sanofi, Abbvie, Lillie. Claudia Giofrè has been a member of scientific board/speaker/clinical study investigator for AbbVie, Celgene, Janssen, Novartis, Sanofi. Serena Lembo has no conflict of interest to declare. Claudia Leporati has served on advisory boards for Novartis, AbbVie, Leo Pharma, Almirall. Francesco Loconsole served on advisory boards and/or received honoraria for lectures from Abbvie, Jansen-Cilag, Novartis, Lilly, Sanofi. Giovanna Malara has been a member of scientific board/speaker/clinical study investigator for AbbVie, Celgene, Janssen, Eli-Lilly, Novartis, Sanofi. Ketty Peris reports personal fees from Abbvie, personal fees from Almirall, personal fees from Lilly, personal fees from Galderma, personal fees from Leo Pharma, personal fees from Pierre Fabre, personal fees from Novartis, personal fees from Sanofi, personal fees from Sun Pharma, personal fees from Janssen, outside the submitted work. Antonio Giovanni Richetta has been a member of scientific board/speaker/clinical study investigator for AbbVie, Celgene, Janssen, Eli-Lilly, Novartis. Paola Savoia has no conflict of interest to declare. Rossana Tiberio has no conflict of interest to declare. Massimo Travaglini has no conflict of interest to declare. Maria Teresa Uzzauto has no conflict of interest to declare. Luca Bianchi has been speaker or board member for Abbie, Novartis, Eli Lilly, Biogen, Sanofi, Leo Pharma, Janssen. The authors report no other conflicts of interest in this work., (© 2021 Argenziano et al.)