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Chenyu Tang,1 Ping Lin,2 Yige Zhao,1 Panpan Wang,1 Ping Wang3 1Department of Dermatology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Gerontology, Hangzhou Third People’s Hospital, Hangzhou, People’s Republic of China; 3Department of Dermatology, Hangzhou Third People’s Hospital, Hangzhou, People’s Republic of ChinaCorrespondence: Ping Wang, Department of Dermatology, Hangzhou Third People’s Hospital, Xihu Avenue No. 38, Hangzhou, Zhejiang, 310009, People’s Republic of China, Tel +86-13588812862, Email dermwang@aliyun.comPurpose: To summarize the clinical, histopathological and therapeutic features of senile gluteal dermatosis.Patients and Methods: Retrospective analysis of 230 cases who visited the outpatient clinic of Hangzhou No. 3 People’s Hospital for skin lesions on the buttocks and hips from 2018.8– 2023.8 were included in the study, basic clinical information was collected, and they were subjected to physical examination of the buttocks and hips, and 36 cases were senile gluteal dermatosis, of which 7 underwent histopathological biopsy.Results: A total of 230 patients were included, of which 36 were diagnosed with geriatric buttock dermatosis, with a mean age of (84.2± 12.6) years, mean body mass index of (21.7± 3.8) kg/m2, and a male to female ratio of 2:1. There was a significant correlation between the occurrence of the disease and age, gender, body mass index, sedentary time, type of chair used, and hypertension (P< 0.05). The severity of the lesions may be associated with longer sitting time and prolonged use of bamboo chairs (P< 0.05). Histopathologic changes were not specific. The skin lesions could subside after general treatment such as improvement of lifestyle, use of pressure-reducing air mattresses, salicylic acid cream, and moisturizing creams.Conclusion: Senile gluteal dermatosis is a common senile physical dermatosis, mainly manifested a

Panpan Wang,1 Chenyu Tang,1 Yige Zhao,1 Ping Wang2 1Department of Dermatology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Dermatology, Hangzhou Third People’s Hospital, Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Ping Wang, Department of Dermatology, Hangzhou Third People’s Hospital, Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Westlake Ave 38, Hangzhou, People’s Republic of China, Tel +8613588812862, Email dermwang@aliyun.comAbstract: Dyschromatosis symmetrica hereditaria (DSH) is a pigmented genetic skin disorder with an incompletely understood pathogenesis characterized by reticular hyper- and hypopigmented skin patches on the dorsal aspect of the extremities, freckle-like patches on the face, and unaffected palms and feet. There is no effective treatment available. Glucose-6-phosphate dehydrogenase (G6PD) deficiency has not been reported in the literature of DSH. We describe for the first time a case of DSH with G6PD deficiency and a family history of psychosis.Keywords: dyschromatosis symmetrica hereditaria, glucose-6-phosphate dehydrogenase deficiency, psychosis, ADAR1

Chenyu Tang,1 Ping Wang2 1Department of Dermatology, Hangzhou Third People’s Hospital, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 2Department of Dermatology, Hangzhou Third People’s Hospital; Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Ping Wang, Department of Dermatology, Hangzhou Third People’s Hospital; Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Westlake Ave 38, Hangzhou, People’s Republic of China, Tel +8613588812862, Email dermwang@aliyun.comAbstract: Linear atrophoderma of Moulin (LAM) is a rare acquired skin disease. Clinically, LAM is characterized by hyperpigmented and atrophic unilateral band-like or linear dermatoses of variable size following the Blaschko lines. The lesions do not present induration or sclerosis. Its course is asymptomatic without systemic involvement or progression. The etiology of LAM is still unclear. Based on the characteristics of its skin lesions distributed along the Blaschko lines, some scholars speculate that its pathogenesis may be related to chromosome mosaicism. We hereby present a case report of LAM in a 29-year-old Chinese female who had persistent brown patches distributed along the Blaschko lines on the left lower back, buttocks, and lower limbs with positive antinuclear antibody (ANA, 1:320, nucleolar type) and elevated immunoglobulin M (3.47 g/L). Including this case, a total of 6 LAM cases have been reported to have abnormal serum immunological markers.Keywords: linear atrophoderma of Moulin, atrophy, Blaschko lines