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1. Early Real-World Physician Experience with an Intracanalicular Dexamethasone Insert

Author

Matossian,Cynthia, Stephens,John D, Rhee,Michelle K, Smith,Stephen E, Majmudar,Parag A, Gollamudi,Subba Rao, Patel,Ravi H, Rosselson,Maria E, Bauskar,Aditi, Montieth,Alyssa, Silva,Fabiana Q, Vantipalli,Srilatha, Gibson,Andrea, Metzinger,Jamie Lynne, Goldstein,Michael H, Matossian,Cynthia, Stephens,John D, Rhee,Michelle K, Smith,Stephen E, Majmudar,Parag A, Gollamudi,Subba Rao, Patel,Ravi H, Rosselson,Maria E, Bauskar,Aditi, Montieth,Alyssa, Silva,Fabiana Q, Vantipalli,Srilatha, Gibson,Andrea, Metzinger,Jamie Lynne, and Goldstein,Michael H

Abstract

Cynthia Matossian,1 John D Stephens,2 Michelle K Rhee,3 Stephen E Smith,4 Parag A Majmudar,5 Subba Rao Gollamudi,6 Ravi H Patel,7 Maria E Rosselson,5 Aditi Bauskar,8 Alyssa Montieth,8 Fabiana Q Silva,8 Srilatha Vantipalli,8 Andrea Gibson,8 Jamie Lynne Metzinger,8 Michael H Goldstein8 1CM Associates, LLC, New Hope, PA, USA; 2Tyson Eye, Fort Myers, FL, USA; 3Icahn School of Medicine at Mount Sinai, New York, NY, USA; 4Eye Associates, Fort Myers, FL, USA; 5Chicago Cornea Consultants, Ltd., Chicago, IL, USA; 6Eye Specialty Group, Memphis, TN, USA; 7Eye Associates of Central Texas, Round Rock, TX, USA; 8Ocular Therapeutix, Inc., Bedford, MA, USACorrespondence: Srilatha Vantipalli, Ocular Therapeutix, Inc, 24 Crosby Drive, Bedford, MA, 01730, USA, Tel +1 413-230-7242, Email SVantipalli@ocutx.comPurpose: To describe the early real-world experience of physicians with an intracanalicular dexamethasone insert (DEX) in patients undergoing cataract surgery and to capture the clinical impact of adopting this therapy.Patients and Methods: 23 United States sites including Ambulatory Surgical Center Setting (ASC) and Outpatient Clinical settings. Respondents were physicians who had early experience with DEX in cataract surgery patients. This was a Phase 4 experiential cross-sectional survey study comprised of 3 sequential online physician surveys. Descriptive statistics summarized the surveys’ responses to determine the early impressions of the respondents.Results: Forty-two physicians completed surveys. On average, physicians reported feeling comfortable administering DEX after placing 3 inserts (mean 2.7; standard deviation 1.9). Most physicians (92%) were satisfied with DEX, and all physicians (100%) reported that DEX improved patient compliance. Most physicians (62.5%) indicated they would highly prefer DEX over traditional steroid eyedrops for the management of post-surgical inflammation and pain.Conclusion: The surveys exploring the early use of DEX suggest that DEX is a cl

Published
2022

2. Acupuncture and dry eye: current perspectives. A double-blinded randomized controlled trial and review of the literature

Author

Dhaliwal,Deepinder K, Zhou,Siwei, Samudre,Sandeep S, Lo,Nathan J, and Rhee,Michelle K

Subjects
Clinical Ophthalmology
Abstract

Deepinder K Dhaliwal,1 Siwei Zhou,1 Sandeep S Samudre,2 Nathan J Lo,3 Michelle K Rhee41Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Department of Ophthalmology, Eastern Virginia Eye Institute, Norfolk, VA, USA; 3Department of Medicine, Duke University Hospital, Durham, NC, USA; 4Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USAPurpose: Dry eye disease (DED) is a common disorder that negatively impacts quality of life and vision. Prior studies have shown some benefit of acupuncture for dry eye, but very few have included control group to mitigate placebo effect. This study was designed with a sham acupuncture control group to evaluate true acupuncture treatment effect.Methods: This is a prospective, randomized, double-blinded, sham-acupuncture-controlled trial. Acupuncture treatment for dry eye was performed as per the Niemtzow Protocol. Twenty-four patients received true acupuncture and twenty-five received sham acupuncture. Treatment efficacy was assessed by the Ocular Surface Disease Index (OSDI) Questionnaire, ocular surface staining, tear flow, tear film break-up time (TBUT), and a general questionnaire. Atmospheric data were collected to control for the effect of atmospheric conditions on symptoms of dry eye.Results: OSDI scores in the treatment group improved compared to baseline (1 week, p

Published
2019

3. Clinical utility of cyclosporine (CsA) ophthalmic emulsion 0.05% for symptomatic relief in people with chronic dry eye: a review of the literature

Author

Rhee,Michelle K and Mah,Francis S

Subjects
Clinical Ophthalmology, eye diseases
Abstract

Michelle K Rhee,1 Francis S Mah21Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Scripps Clinic Torrey Pines, La Jolla, CA, USAAbstract: To review the literature on the efficacy of cyclosporine (CsA) ophthalmic emulsion 0.05% on symptomatic relief in chronic dry eye disease. There is consistent evidence of objective improvements in chronic dry eye disease (Schirmer score, corneal and interpalpebral dye staining, and tear breakup time) with CsA, but variable results with symptomatic improvement, possibly due to patient tolerance of CsA, similar comforting effect with artificial tears and CsA vehicle, and the inherent subjective nature of symptom monitoring and analysis. This review explores the literature on CsA with special attention to symptomatic relief.Keywords: dry eye, cyclosporine, symptoms

Published
2017

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