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Mihaela Dediu,1– 3 Ioana Mihaiela Ciuca,1– 3 Monica Steluta Marc,4 Estera Boeriu,1 Liviu Laurentiu Pop1 1Pediatric Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania; 2National Cystic Fibrosis Centre, Timisoara, Romania; 3“Pius Branzeu” County Hospital, Timisoara, Romania; 4Pulmonology Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, RomaniaCorrespondence: Ioana Mihaiela CiucaPediatric Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, RomaniaTel + 40 744 513 283Fax +40 356 494529Email ciuca.ioana@umft.roPurpose: The aim of this cross-sectional study was to identify the major factors influencing pulmonary function in CF patients from western side of Romania.Patients and Methods: The study enrolled 51 patients with CF between the ages of 6 and 27.8 years who were monitored at regular visits to the National Cystic Fibrosis Centre and Pius Branzeu County Hospital in Timisoara, Romania, over a period of 2 years. The relationships between lung function, as measured by forced expiratory volume in 1 s (FEV1), with patient age, sex, body mass index (BMI), pancreatic insufficiency (PI), microbial infection, CF-related diabetes (CFRD), CF-associated liver disease (CFLD), and physical activity < 30 min/day, were evaluated by multivariate regression analysis.Results: The results showed that FEV1 was 0.32% higher for each increase in percentile of BMI (95% confidence interval: 0.034– 0.619). In addition, mean FEV1 was 1.52% lower with every year rise of age. PI and female sex increased the risk of impaired lung function (FEV1 < 60%). The factors most closely correlated with pulmonary function in pediatric CF patients were current age (negative) and BMI (positive).Conclusion: The findings of this study, in combination with what is known from other studies in CF, suggest that a