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2 results on '"Jan, Tariq"'

1. Antimicrobial potential of green synthesized CeO2 nanoparticles from Olea europaea leaf extract

Author

Maqbool,Qaisar, Nazar,Mudassar, Naz,Sania, Hussain,Talib, Jabeen,Nyla, Kausar,Rizwan, Anwaar,Sadaf, Abbas,Fazal, and Jan,Tariq

Subjects
International Journal of Nanomedicine
Abstract

Qaisar Maqbool,1 Mudassar Nazar,1 Sania Naz,2 Talib Hussain,3 Nyla Jabeen,4 Rizwan Kausar,5 Sadaf Anwaar,4 Fazal Abbas,6,7 Tariq Jan6 1Department of Biotechnology, Virtual University of Pakistan, Lahore, Pakistan; 2Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan; 3National Institute of Vacuum Science and Technology (NINVAST), Islamabad, Pakistan; 4Department of Biotechnology and Bioinformatics Lab., International Islamic University, Islamabad, Pakistan; 5Department of Chemistry, University of Sargodha, Sargodha, Pakistan; 6Department of Physics, International Islamic University, Islamabad, Pakistan; 7Interdisciplinary Research Organization, University of Chakwal (UOC), Chakwal, Pakistan Abstract: This article reports the green fabrication of cerium oxide nanoparticles (CeO2 NPs) using Olea europaea leaf extract and their applications as effective antimicrobial agents. O. europaea leaf extract functions as a chelating agent for reduction of cerium nitrate. The resulting CeO2 NPs exhibit pure single-face cubic structure, which is examined by X-ray diffraction, with a uniform spherical shape and a mean size 24 nm observed through scanning electron microscopy and transmission electron microscopy. Ultraviolet-visible spectroscopy confirms the characteristic absorption peak of CeO2 NPs at 315 nm. Fourier transform infrared spectroscopy reflects stretching frequencies at 459 cm-1, showing utilization of natural components for the production of NPs. Thermal gravimetric analysis predicts the successful capping of CeO2 NPs by bioactive molecules present in the plant extract. The antimicrobial studies show significant zone of inhibition against bacterial and fungal strains. The higher activities shown by the green synthesized NPs than the plant extract lead to the conclusion that they can be effectively used in biomedical application. Furthermore, reduction of cerium salt by plant extract will reduce environmental impact over chemical synthesis. Keywords: XRD, SEM, TEM, FTIR, antibacterial, antifungal, nanomedicine, green fabrication

Published
2016

2. Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria

Author

Jan,Tariq, Iqbal,Javed, Ismail,Muhammad, Zakaullah,M, Naqvi,Sajjad Haider, Badshah,Noor, Jan,Tariq, Iqbal,Javed, Ismail,Muhammad, Zakaullah,M, Naqvi,Sajjad Haider, and Badshah,Noor

Abstract

Tariq Jan,1 Javed Iqbal,1 Muhammad Ismail,2 M Zakaullah,3 Sajjad Haider Naqvi,4 Noor Badshah51Laboratory of Nanoscience and Technology, Department of Physics, International Islamic University, Islamabad, Pakistan; 2Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan; 3Department of Physics, Quaid-i-Azam University, Islamabad, Pakistan; 4Department of Biochemistry, University of Karachi, Karachi, Pakistan; 5Department of Basic Science, University of Engineering and Technology, Peshawar, PakistanAbstract: Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacterial activity of undoped ZnO and tin (Sn) doped ZnO nanostructures synthesized by a simple, versatile, and wet chemical technique have been investigated against Escherichia coli, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa bacterial strains. It has been interestingly observed that Sn doping enhanced the inhibitory activity of ZnO against S. aureus more efficiently than the other two bacterial strains. From cytotoxicity and reactive oxygen species (ROS) production studies it is found that Sn doping concentration in ZnO does not alter the cytotoxicity and ROS production very much. It has also been observed that undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells. The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter. Structural investigations have confirmed the formation of a single phase wurtzite structure of ZnO. The morphology of ZnO nanostructures is found to vary from spherical to

Published
2013

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