1. Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer
- Author
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Ya-Lan Wang, Ling Yin, Ming Xiao, Chuan-Ling Wang, Qing-Shu Li, Lian Yang, Ming Li, Xian Li, and Yi Tang
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,mono-ADP-ribosylation ,colorectal cancer ,03 medical and health sciences ,High morbidity ,0302 clinical medicine ,Internal medicine ,medicine ,Epigenetics ,Pathological ,Original Research ,business.industry ,Mortality rate ,medicine.disease ,030104 developmental biology ,Cancer Management and Research ,030220 oncology & carcinogenesis ,Colorectal tissue ,ADP-ribosylation ,immunohistochemistry ,Immunohistochemistry ,business ,Corrigendum - Abstract
Chuan-Ling Wang, Yi Tang, Ming Li, Ming Xiao, Qing-Shu Li, Lian Yang, Xian Li, Ling Yin, Ya-Lan Wang Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Ya-Lan WangDepartment of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaTel +86 13628308360Fax +86 23 6848 5111Email wangyalan@cqmu.edu.cnBackground: Colorectal cancer remains a major public health problem with high morbidity and mortality rates. In the search for the mechanisms of colorectal cancer occurrence and development, increasing attention has been focused on epigenetics. The overall level of Mono-ADP-ribosylation, an epigenetic, has not been investigated now. The aim of our study was to analysis of the overall level of mono-ADP-ribosylation in colorectal cancer.Methods: Immunohistochemistry was used to investigate the level of mono-ADP-ribosylation in colorectal cancer and normal colorectal adjacent tissue from 64 CRC patients. The data of patient demographic, clinical and pathological characteristics were acquired and analyzed.Results: Mono-ADP-ribosylation was present in both colorectal adenocarcinoma and normal colorectal tissue. The overall level of mono-ADP-ribosylation in colorectal cancer was significantly higher than that in normal colorectal adjacent tissue. In the nucleus, the majority of samples in the high-level group were colorectal adenocarcinoma (55/64), but the opposite was true for normal colorectal tissues (7/32). In particular, increases in the level of mono-ADP-ribosylation in the cytoplasm of colorectal cancer cells was associated with a greater invasion depth of the tumor.Conclusion: The increased level of mono-ADP-ribosylation in colorectal cancer enhances tumor invasion, which suggests that mono-ADP-ribosylation is involved in the development of colorectal cancer and may become a new direction to solve the problem of colorectal cancer.Keywords: mono-ADP-ribosylation, colorectal cancer, immunohistochemistry
- Published
- 2021