1. Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
- Author
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Zhao,Yuying, Tan,Hanxu, Zhang,Juping, Pan,Bo, Wang,Neng, Chen,Tongkai, Shi,Yafei, Wang,Zhiyu, Zhao,Yuying, Tan,Hanxu, Zhang,Juping, Pan,Bo, Wang,Neng, Chen,Tongkai, Shi,Yafei, and Wang,Zhiyu
- Abstract
Yuying Zhao,1 Hanxu Tan,2 Juping Zhang,1,3 Bo Pan,1 Neng Wang,2 Tongkai Chen,4 Yafei Shi,1,2 Zhiyu Wang1,3,5 1State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Peopleâs Republic of China; 2The Research Center for Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, Peopleâs Republic of China; 3Guangdong-Hong Kong-Macau Joint Laboratory on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, Peopleâs Republic of China; 4Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, Peopleâs Republic of China; 5Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong, Peopleâs Republic of ChinaCorrespondence: Zhiyu Wang; Yafei Shi, Email wangzhiyu@gzucm.edu.cn; shiyafei@gzucm.edu.cnAbstract: Lipid-structured vesicles have been applied for drug delivery system for over 50 years. Based on their origin, lipid-structured vesicles are divided into two main categories, namely synthetic lipid vesicles (SLNVEs) and vesicles of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-cancer drugs, their biocompatibility is poor and degradation of exogenous substances is a potential risk. Unlike SLNVEs, MDVEs have excellent biocompatibility but are limited by a lack of stability and a risk of contamination by dangerous pathogens from donor cells. Since the first discovery of plant-derived vesicles (PDVEs) in carrot cell supernatants in 1967, emerging evidence has shown that PDVEs integrate the advantages of both SLNVEs and MDVEs. Notably, 55 years of dedicated research has indicated that PDVEs are an ideal candidate vesicle fo
- Published
- 2023