1. Health care use before a diagnosis of primary intracranial tumor: a Danish nationwide register study
- Author
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Charlotte Nygaard, Henry Jensen, Jakob Christensen, and Peter Vedsted
- Subjects
medicine.medical_specialty ,Pediatrics ,Neurology ,diagnosis ,Epidemiology ,Denmark ,Population ,Logistic regression ,Benign tumor ,03 medical and health sciences ,0302 clinical medicine ,Health care ,medicine ,Sampling (medicine) ,Clinical Epidemiology ,health care services ,030212 general & internal medicine ,education ,Original Research ,general practice ,brain neoplasms ,education.field_of_study ,business.industry ,Cancer ,Odds ratio ,medicine.disease ,030220 oncology & carcinogenesis ,business - Abstract
Dette studie undersøger brugen af sundhedsvæsenet blandt voksne to år før diagnosticeringen af en godartet eller ondartet primær hjernetumor i Danmark. Resultaterne viser, at der generelt er en betydeligt større klinisk aktivitet i både primær- og sekundærsektoren forud for en hjernetumor-diagnose. Patienterne med en godartet hjernetumor havde øget brug af sundhedskontakter fra op til 2 år før diagnosetidspunktet. Derimod steg brugen af sundhedsydelser for patienterne med en ondartet tumor først relativt få måneder (fra 4 mdr.) før diagnosen. Meget tyder derfor på, at tiden fra første symptom til diagnosticering er relativt kort for patienter med en ondartet hjernetumor, mens den generelt er længere for patienter med en godartet hjernetumor, da mange af dem har henvendt sig til lægen på grund af symptomer helt op til 2 år før diagnosen. Dette kan betyde, at et ”diagnostisk vindue” står på klem og giver mulighed for en tidligere diagnose af særligt godartede hjernetumorer. Introduction: Detailed knowledge of prediagnostic health care use among patients with primary intracranial tumors is sparse. We aimed to investigate the health care use among adults during the 2 years preceding a diagnosis of a benign or malignant primary intracranial tumor in Denmark.Methods: We conducted a population-based matched cohort study using historical data from Danish nationwide registries, including all patients aged 30-90 years diagnosed with a first-time primary intracranial tumor from January 1, 2009 to December 31, 2014, and with no prior cancer diagnosis (n=5,926). For each patient, ten comparison subjects were identified using density sampling. We analyzed differences in the frequency and timing of health care use within general practice, physiotherapy, radiology, ear -nose -throat, ophthalmology, neurology, and psychiatry. Odds ratios of having multiple contacts were calculated using a conditional logistical regression model. Monthly incidence rate ratios were estimated using a negative binomial regression model.Results: Of all patients, 62% had a benign tumor. Patients with benign tumors were more likely to have multiple consultations with health care providers in the period 2-12 months prior to diagnosis and to have increased rates of consultations 1-24 months prior to diagnosis, depending on health service.Conclusion: Patients diagnosed with a benign or a malignant primary intracranial tumor use the health care services differently. Increased health care use is seen within relatively close proximity to the diagnosis for patients with malignant tumors. However, patients with benign tumors have increased health care use from up to 2 years prior to diagnosis; this suggests a window of opportunity for earlier diagnosis.
- Published
- 2018
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