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Mahdi Al Dhafiri,1 Feroze Kaliyadan,2 Sara Almukhaimar,3 Fatemah Abdulrahman Alsultan,3 Elham Al Hayim,3 Roaa Alnaim,3 Alaa Aldossari3 1Department of Dermatology, College of Medicine, King Faisal University, Al-Ahsa, Eastern Province, Saudi Arabia; 2Department of Dermatology, Sree Narayana Institute of Medical Sciences, Chalaka, Ernakulam, Kerala, India; 3College of Medicine, King Faisal University, Al-Ahsa, Eastern Province, Saudi ArabiaCorrespondence: Sara Almukhaimar, College of Medicine, King Faisal University, Al-Ahsa, Eastern Province, 31982, Saudi Arabia, Tel +966560492224, Email 219014240@student.kfu.edu.saPurpose: Acne is a chronic inflammatory skin disease with a high prevalence in Saudi Arabia. Isotretinoin is used to treat severe, resistant nodulocystic acne. Side effects include joint discomfort, headache, mucosal dryness, and nose bleeds. Elevated lipids and liver enzymes have also been recorded. The study goal is to identify the prevalence of increased lipid levels during and after isotretinoin use.Patients and Methods: This retrospective study was conducted in the dermatology polyclinic at King Faisal University, Al-Ahsa, Saudi Arabia. It included adults of different age groups diagnosed with acne vulgaris and treated with oral isotretinoin between January 2021 and December 2022. Parameters included baseline laboratory tests and follow-up laboratory results of cholesterol and triglycerides.Results: Among 88 patients, 48.9% were aged 21– 23 years, with females dominating. In total, 47.7% of patients started using isotretinoin at age 20 years or less, with starting doses ranging from 10 to 20 mg. Fifty percent of the patients had five months or more of treatment duration and only 6.8% of the patients had previously used isotretinoin. For the cholesterol and triglycerides, 87.5% of patients had normal pre-treatment with cholesterol and 90.9% with triglycerides, followed by 81.8% and 95.5% in the second reading, respectively. In the last reading, resul