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Mekonnen Tsehay, Asmare Belete, Mogesie Necho Wollo University, College of Medicine and Health Science, Department of Psychiatry, South Wollo, Dessie, EthiopiaCorrespondence: Mekonnen TsehayLecturer of Psychiatry, Wollo University, Po. Box: 1145, South Wollo, Dessie, EthiopiaTel +251912991308Email jimma1760@gmail.comBackground: The outbreak of Coronavirus Disease 2019 (COVID-19) has caused serious threats to people’s health and lives in the world. The health-care professionals are bravely fighting on the front lines of the pandemic everywhere in the world. Our study is the first to study psychological distress and coping status among health-care professionals of Dessie town, Ethiopia during the unbridled time of the COVID-19 outbreak.Methods: A cross-sectional internet-based study was conducted between June 20 and July 13, 2020. The questionnaires included the demographic information, COVID-19 related questions, Kasseler-10 to assess psychological distress level and Brief Resilient Coping Scale, and Oslo-3 social support scale questionnaire were employed.Results: A total of 423 participants were involved in the study with a response rate of 100%. The mean age of respondents was 34.5 years (SD = ± 8.45 years). The prevalence of psychological distress among participants was 42%. Of these 18%, 11%, and 13% had mild, moderate, and severe psychological distress levels. Being married, being nurses and pharmacies, current substance users, working in emergency and outpatient departments, history of chronic medical illness, brief resilient coping level, and social support level were particularly associated with high psychological distress.Conclusion: Health-care professionals are experiencing a substantial level of psychological distress. In addition to other modifying factors coping level and social support was a significant predictor of psychological distress among health-care professionals. These findings should inform the implementation of interventions that increase coping resilience and social support to mitigate the impact of psychological distress among health-care professionals.Keywords: COVID-19, health care professionals, psychological distress, coping, social support