1. Oxidant/antioxidant status, paraoxonase activity, and lipid profile in plasma of ovariectomized rats under the influence of estrogen, estrogen combined with progesterone, and genistein
- Author
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Mehmet Sait Icen, Elif Ağaçayak, Serdar Başaranoğlu, İbrahim Kaplan, Fatih Mehmet Findik, Talip Gül, Osman Evliyaoglu, and Senem Yaman Tunç
- Subjects
medicine.medical_specialty ,medicine.drug_class ,Ovariectomy ,Pharmaceutical Science ,Genistein ,menopause ,medicine.disease_cause ,Antioxidants ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Internal medicine ,Drug Discovery ,medicine ,Animals ,Progesterone ,Original Research ,Pharmacology ,Drug Design, Development and Therapy ,medicine.diagnostic_test ,Estradiol ,business.industry ,Aryldialkylphosphatase ,Body Weight ,Estrogen Replacement Therapy ,Drospirenone ,Estrogens ,medicine.disease ,Oxidants ,Lipids ,cardiovascular diseases ,Rats ,Menopause ,Endocrinology ,chemistry ,Estrogen ,Ovariectomized rat ,lipids (amino acids, peptides, and proteins) ,Female ,Progestins ,business ,Lipid profile ,Oxidative stress ,Lipoprotein ,medicine.drug - Abstract
Elif Agacayak,1 Serdar Basaranoglu,2 Senem Yaman Tunc,1 Mehmet Sait Icen,1 Fatih Mehmet Findik,1 Ibrahim Kaplan,3 Osman Evliyaoglu,3 Talip Gul1 1Department of Obstetrics and Gynecology, Dicle University School of Medicine, Diyarbakir, Turkey; 2Department of Obstetrics and Gynecology, Idil State Hospital, Sirnak, Turkey; 3Department of Biochemistry, Dicle University School of Medicine, Diyarbakir, Turkey Introduction: The aim of this study was to investigate whether estradiol (E2), E2 combined with progesterone (Prog) (E2/Prog), and genistein (Gen) treatment had antioxidative and antihyperlipidemic effects in the plasma of ovariectomized (OVX) rats.Materials and methods: Adult female Sprague–Dawley rats were divided into five groups. Rats in all groups, except for those in a sham group, underwent bilateral ovariectomy under general anesthesia. The groups were as follows: sham group; control OVX group; group treated with estrogen (0.014 mg/kg 17-β E2); group treated with a combination of E2 and Prog (0.014mg/kg 17-β E2 plus 0.028 mg/kg drospirenone), and group treated with Gen (10 mg/kg/day). Plasma of rats of each treatment group was analyzed to determine the total antioxidant status, total oxidant status, paraoxonase activity, lipid profile, high-density lipoprotein (HDL-chol), low-density lipoprotein (LDL-chol), total cholesterol (Total-C), triacylglycerols, lipoprotein (a), and oxidative stress index.Results: Plasma Total-C levels and body weight increased in all the OVX groups compared with the sham group (P
- Published
- 2015