1. Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
- Author
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James C. Nicholson, Chester G. Wilson, Udayabhanu Jammalamadaka, David Mills, Karthik Tappa, and Jeffery A. Weisman
- Subjects
Sustained delivery ,Materials science ,medicine.drug_class ,Polymers ,Polyesters ,Antibiotics ,Biophysics ,Pharmaceutical Science ,Bioengineering ,Nanotechnology ,Patient care ,Biomaterials ,Drug Delivery Systems ,International Journal of Nanomedicine ,Cell Line, Tumor ,Drug Discovery ,medicine ,Humans ,Patient treatment ,Lactic Acid ,three-dimensional printing ,Original Research ,Cell Proliferation ,Bacteria ,business.industry ,medical device ,Organic Chemistry ,General Medicine ,Tailored treatment ,Anti-Bacterial Agents ,antibacterial ,Drug delivery ,drug delivery ,Printing, Three-Dimensional ,Chemotherapeutic drugs ,Personalized medicine ,Gentamicins ,business - Abstract
Jeffery A Weisman,1 James C Nicholson,2 Karthik Tappa,1 UdayaBhanu Jammalamadaka,1 Chester G Wilson,2 David K Mills1,3 1Center for Biomedical Engineering and Rehabilitation Science, 2Nanosystems Engineering, 3School of Biological Sciences, Louisiana Technical University, Ruston, LA, USAAbstract: Three-dimensional (3D) printing and additive manufacturing holds potential for highly personalized medicine, and its introduction into clinical medicine will have many implications for patient care. This paper demonstrates the first application of 3D printing as a method for the potential sustained delivery of antibiotic and chemotherapeutic drugs from constructs for patient treatment. Our design is focused on the on-demand production of anti-infective and chemotherapeutic filaments that can be used to create discs, beads, catheters, or any medical construct using a 3D printing system. The design parameters for this project were to create a system that could be modularly loaded with bioactive agents. All 3D-printed constructs were loaded with either gentamicin or methotrexate and were optimized for efficient and extended antibacterial and cancer growth-inhibiting cytostatic activity. Preliminary results demonstrate that combining gentamicin and methotrexate with polylactic acid forms a composite possessing a superior combination of strength, versatility, and enhanced drug delivery. Antibacterial effects and a reduction in proliferation of osteosarcoma cells were observed with all constructs, attesting to the technical and clinical viability of our composites. In this study, 3D constructs were loaded with gentamicin and methotrexate, but the method can be extended to many other drugs. This method could permit clinicians to provide customized and tailored treatment that allows patient-specific treatment of disease and has significant potential for use as a tunable drug delivery system with sustained-release capacity for an array of biomedical applications. Keywords: three-dimensional printing, polymers, antibacterial, drug delivery, medical device
- Published
- 2015