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On January 26-27,2004 a workshop on Dissolution,Bioequivalence and Bioavailability was held in Philadelphia,PA,during a three punch snow storm on the east coast. In spite of the bad weather,the attendance was good and the participants brought many questions and the discussions were fruitful. The meeting began with Tahseen Mirza,Ph.D., the conference chairperson,former USP,current Associate Director Analytical and Pharmaceutical Development,Novartis Pharmaceutical Corp, summarizing the objectives of the meeting. He emphasized the significance of establishing a clear objective before developing dissolution methods. It must be specified whether it is a test of pharmaceutical quality or a test of biopharmaceutical quality and then design the method development strategies accordingly. He identified the following ten topics and questions as the focus of the workshop.

This report summarizes the results of the "In Vitro-In Vivo Correlations (IVIVC): Critical Variables for Success" survey orga- nized by the In Vitro Release and Dissolution Testing (IVRDT) and the QbD and Product Performance AAPS Focus Groups. This was a web-based survey conducted over a 26-day period from Wednesday, June 29, 2011, to Sunday, July 24, 2011, and results were initially presented at the 2011 AAPS Annual Meeting and Exposition. The goal was to describe the current views from scientists across academia, industry, and regulatory agencies on the adoption, utility, and benefits of IVIVCs and to begin identifying potentially critical variables for their success. Questions in the survey cover their development, use, and success.