1. Role of nanotechnology in HIV/AIDS treatment: potential to overcome the viral reservoir challenge.
- Author
-
Amiji MM, Vyas TK, and Shah LK
- Subjects
- Acquired Immunodeficiency Syndrome virology, Anti-Retroviral Agents administration & dosage, Anti-Retroviral Agents chemistry, Drug Carriers administration & dosage, Drug Carriers chemistry, HIV Infections virology, Humans, Acquired Immunodeficiency Syndrome drug therapy, Anti-Retroviral Agents therapeutic use, HIV Infections drug therapy, Nanotechnology methods
- Abstract
Insufficient concentrations and very short residence time of the anti-retroviral agents at the cellular and anatomical sites are among major factors that contribute to the failure of eradicating HIV from reservoirs and the development of multidrug resistance against antiretroviral agents. In recent years, nanotechnology-based drug delivery systems have shown remarkable ability to overcome many of the same anatomical and physiological barriers and deliver the therapeutic agents locally at the site of systemic diseases such as cancer.
- Published
- 2006