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Current randomized controlled experimental study was carried out to investigate the beneficial effects of leaf extract of Ficus carica L. (Anjir) leaf extract in gentamicin induced nephrotoxicity. Thirty mice were divided into three groups of 10 mice each. Group A served as control and was given distilled water orally for 8 days. Group B and C were experimental and were treated with gentamicin 200 mg/kg/day intraperitoneally and gentamicin 200 mg/kg/day intraperitoneally with Ficus carica L. (Anjir) leaf extract 400 mg/kg/day orally respectively for a period of 8 days. After 24 hours of experimental period, kidneys of each mouse were dissected and processed for microscopic examination. The histological examination of group A showed normal renal architecture whereas histopathalogical examination of group B showed fragmented tubular basement membrane, tubular degeneration, tubular cast with interstitial inflammation and congestion. Histological examination of group C showed minimal change in renal histology as compared to group B. Gentamicin is a nephrotoxic drug and Ficus carica L. leaf extract has nephroprotective effects against gentamicin induced nephrotoxicity due to its antioxidant properties. [ABSTRACT FROM AUTHOR]