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Nitrated polycyclic aromatic hydrocarbons (NPAHs) are a family of toxicants wide spreading in the environment. In this study, quantitative structural-activity relationship (QSAR) models were developed for the prediction of mutagenicity of NPAHs. Structural descriptors were screened and multiple linear regression (MLR) were performed for developing the QSAR models. Totally 1706 descriptors were obtained based on structural optimization using density functional theory (DFT) at the CPCM-B3LYP/6-311+g (d,p) theoretical level in water. External and leave-one-out cross validation were performed to confirm the predictive ability and the models robustness, respectively. Totally 33 QSAR models were generated using one to eight descriptors, in which the model consisting of 4 descriptors, including Eelec, SIC2, RDF040v and GATS4v, has the highest correlation coefficient (R2=0.8755). This study will contribute to not only the prediction of the mutagenicity of NPAHs, but also the development of QSAR modeling methods of toxicants.

Rural revitalization strategy, precise poverty alleviation, and priority poverty alleviation in the destitute areas, are the three important new problems in rural poverty alleviation and the “three rural” work in recent years in China. Intellectual precision poverty alleviation , is not only the precise poverty alleviation based on the development of intellectual resources and the protection of agricultural intellectual property, but also the knowledge economy way to the rural revitalization strategy in poor areas. The Wuling mountain area is the national demonstration area of priority poverty alleviation, and one of China's important areas of tea producing. This paper analyzed the strategy of the protection of agriculture intellectual property rights of tea industry and intellectual precision poverty alleviation in this area, proposed several suggestions under the rural revitalization strategy, such as: to implement the intellectual property strategy of regions and leading enterprises; to develop agricultural intellectualization and knowledge economy; to inherit the traditional knowledge and cultural heritage; to implement standardization and agricultural industrialization; to construct the regional scientific and technological innovation system; to promote competitiveness and self-generating ability; to establish the geographical indication pillar industry of the regional characteristics; to dock the Belt and Road strategy; to implement regional brand strategy; to develop agricultural and rural informatization; to promote the “internet plus agriculture” intelligence precise poverty alleviation, etc. The paper stated the definition and basic idea of intellectual precision poverty alleviation.

Priority poverty alleviation in the destitute areas, precise poverty alleviation, and rural revitalization strategy, are the three important new problems in rural poverty alleviation and the “three rural” work in recent years in China. “The world's selenium capital” Enshi city is located in the Wuling mountain area, which is one of the main battlefields of the rural poverty alleviation in China, which has the characteristics of Se-rich industry and animal husbandry. This paper describes the selenium resources, animal husbandry industry, animal husbandry resources, national poverty villages and so on in the city. From the perspectives of industrialization, informatization, intellectualization and development of intellectual animal husbandry and knowledge economy, this paper studies the development and utilization of the intellectual resources in the animal husbandry and the strategy of intellectual precision poverty alleviation based on “internet + Se-rich animal husbandry” in Enshi. A few suggestions are put forward under the rural revitalization strategy.

Rural revitalization strategy, precise poverty alleviation and priority poverty alleviation in the destitute areas, are the three important new problems in the “three rural” work and rural poverty alleviation in recent years in China. Wufeng tujia autonomous county, Changyang tujia autonomous county, Zigui county in Yichang city, are located in the “main battlefield” of the national poverty alleviation — the Wuling mountain area. This paper introduces the agricultural intellectual property rights of the three counties' patents related to agriculture, trademarks, geographical indications, agricultural biological genetic resources, traditional knowledge, and new plant varieties. Based on the perspective of traditional knowledge, the paper analyzes the rural revitalization strategy and intellectual precision poverty alleviation, and puts forward ten suggestions.

Priority poverty alleviation in the destitute areas and precise poverty alleviation, are the two important new problems in rural poverty alleviation and the “three rural” work in recent years in China. Lichuan city has 50 national poverty villages, is located in the “main battlefield” of the national poverty alleviation—the Wuling mountain area. This paper introduces the agricultural intellectual property rights of the city's geographical indications, agricultural biological genetic resources, traditional knowledge, trademarks, patents related to agriculture and new plant varieties, analyzes the strategies of agricultural intellectual property protection and intelligent precision poverty alleviation under the rural revitalization strategy, and puts forward some suggestions.