1. Use of automatic methods in fluxes with spectrophotometric detection in the determination of diclofenac sodium in pharmaceutical formulations and body fluids
- Author
-
Rayone Wesly Santos de Oliveira, Danila Teresa Valeriano Alves, Wellington da Silva Lyra, Hilton Costa Louzeiro, Victor Elias Mouchrek Filho, Adriana Pereira Everton, Paulo Roberto Barrros Gomes, Jonas Batista Reis, and Maria Alves Fontenele
- Subjects
Detection limit ,diclofenaco de sódio ,Chromatography ,Sequential injection analysis ,oxidação ,Chemistry ,oxidation ,Relative standard deviation ,FIA-Multicomutation ,Diclofenac Sodium ,sequential injection analysis ,Flow system ,Sequential injection ,Diclofenac ,medicine ,FIA-multicomutação ,General Earth and Planetary Sciences ,espectrofotometria ,spectrophotometry ,sodium diclofenac ,análise por injeção sequencial ,General Environmental Science ,medicine.drug - Abstract
portuguesEste trabalho descreveu e comparou quatro estudos entre si que utilizaram metodos automaticos em fluxo com deteccao espectrofotometrica e a reacao de oxidacao do diclofenaco para determinar diclofenaco em formulacoes farmaceuticas e fluidos corporais. Para isso, utilizamos os seguintes artigos: Versatility of a multicommuted flow system in the spectrometric determination of three analytes, Sequential injection spectrophotometric method for the assay of anti-inflammatory diclofenac sodium in pharmaceutical preparations, Screening of conditions controlling spectrophotometric sequential injection analysis e Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations e detalhamos as metodologias empregadas, os resultados, conclusoes obtidas e comparamos entre eles os limites de deteccao, desvio padrao relativo e a frequencia analitica. Os resultados mostraram diferencas significativas entre metodos empregados e a utilizacao do Sistema automatico do tipo Analise por Injecao Sequencial, apesar deste possuir menor frequencia analitica. EnglishThis study described and compared four studies that used automatic flow methods with spectrophotometric detection and the oxidation reaction of diclofenac to determine diclofenac in pharmaceutical formulations and body fluids. For this, the following articles were used: Versatility of a multicommuted flow system in the spectrometric determination of three analytes, Sequential injection spectrophotometric method for the assay of anti-inflammatory diclofenac sodium in pharmaceutical preparations, Screening of conditions controlling spectrophotometric sequential injection analysis and Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations and we detail the methodologies used, the results, the conclusions obtained and compare the limits of detection, relative standard deviation and analytical frequency. The results showed significant differences between the employed methods and the use of the Automatic System of the Sequential Injection Analysis type, although this one has a lower analytical frequency.
- Published
- 2019