1. Aetiology and treatment of chronic heart failure with reduced left ventricular function.
- Author
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Larsen AH, Lauridsen TK, Vishram-Nielsen J, Vase H, Vraa S, Wolsk E, Barasa A, Søholm H, Køber L, and Dridi NP
- Subjects
- Humans, Chronic Disease, Angiotensin Receptor Antagonists therapeutic use, Sodium-Glucose Transporter 2 Inhibitors therapeutic use, Stroke Volume, Angiotensin-Converting Enzyme Inhibitors therapeutic use, Heart Failure drug therapy, Heart Failure physiopathology, Mineralocorticoid Receptor Antagonists therapeutic use, Adrenergic beta-Antagonists therapeutic use, Ventricular Dysfunction, Left drug therapy, Ventricular Dysfunction, Left physiopathology
- Abstract
Heart failure with reduced ejection fraction is a syndrome consisting of symptoms (dyspnoea, fatigue, swelling) and/or signs of congestion (pulmonary crackles, oedema). It is caused by structural and/or functional pathologies, most commonly ischaemic heart disease, entailing elevated cardiac filling pressures and can result in low cardiac output. Medical treatment has evolved during the recent decades as outlined in this review, and a 4-pillar treatment strategy is recommended including a renin-angiotensin-aldosterone system blocker or sacubitril/valsartan, a betablocker, a mineralocorticoid antagonist, and an SGLT2 inhibitor., (Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.)
- Published
- 2024
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