1. [Vascular endothelial growth factor therapy in ischaemic heart disease].
- Author
-
Qayyum AA, Joshi FR, Lund LD, Søndergaard RH, and Kastrup J
- Subjects
- Humans, Myocardium, Neovascularization, Pathologic, Vascular Endothelial Growth Factors, Myocardial Ischemia drug therapy, Vascular Endothelial Growth Factor A
- Abstract
Atherosclerosis of coronary arteries can result in a hypoxic state where myocardial cells may become dysfunctional or die. The oxygen sensing transcription factor hypoxia inducible factor 1 responds to low oxygen levels by elevating the production of angiogenic growth factors, such as vascular endothelial growth factor (VEGF). Despite this, endogenous processes and conventional therapies are inefficient in some patients. To stimulate angiogenesis, VEGF has been injected into the myocardium. As stated in this review, this therapy has so far been proven safe and studies are conducted in several countries, including Denmark.
- Published
- 2020