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Paddy-wheat crop rotation is responsible for declining soil health, underground water table, arising new micronutrient deficiencies, new weed flora, and resistance to herbicides, declining both land and water productivity and is claimed to be capital and energy-intensive, more particularly in emerging countries. This is further aggravated when micronutrients are deficient, particularly zinc (Zn), which plays an important role in human health, especially in developing countries. Zn biofortification is a technique in which the inherent Zn status of the edible portion of plants is improved by simply spraying a Zn solution onto the crop or through a soil application at a predetermined stage and a proper dose. The concentration of Zn within a wheat grain is genotype-dependent and interacts with the environment, inducing variation in a grain’s concentration of micronutrients. Grain quality parameters are positively correlated with a higher dose of nitrogen in the late reproductive stage. Broadcasting of ZnSO4·7H2O at 62.5 kg ha−1 and foliar application of Zn chelates such as Zn–HEDP (C) at 2 g L−1, Zn–HEDP (L) at 3 g L−1, or a 0.4–0.5% ZnSO4 solution during grain development stage enhanced the growth, productivity, and micronutrients concentration in the edible portion of the plant which further improves the quality of wheat grains and ultimately improves human health in the region. Given the central importance to Zn in cereal-based nutrition, zinc biofortification appears as an innovative technology to alleviate the zinc deficiency in human health, especially on the Indian subcontinent, by applying Zn either as a foliar or soil application.

Although new-born screening (NBS) for classical congenital adrenal hyperplasia (C-CAH) has been available for decades, it is not widely implemented. We assessed the usefulness of introducing NBS for C-CAH, by analyzing presenting status of infants with C-CAH, over the past two decades, in Sri Lanka. This retrospective clinic-based study, from the largest tertiary children's hospital in Sri Lanka, analyzed initial presenting features of children with C-CAH from 1999 to 2018, in the absence of NBS for CAH, and included gender-based comparisons. Features suggestive of impending adrenal-crisis were seen at initial presentation in >80 % (dehydration 70%, hyponatremia 65%, hyperkalemia 47%, vomiting 45%, hypoglycemia 22%, collapse 20%). Hyperpigmentation was seen in 78%, and consanguinity in 27%. There were fewer affected males (n = 12) compared to females (n = 28). Most girls (96%) had virilized genitalia, and 16 faced uncertainty about gender at birth. Median age at diagnosis was 20 days. More than 70% of children had SW-CAH (males = 9 and females = 20). There were fewer males with SW-CAH, and all had features of impending adrenal crisis, including severe hyponatremia in 50%, while 62% of girls also developed hyponatremia and 33% had hyperkalemia, prior to treatment. Treatment of SW-CAH was initiated at a median age of 30 days in boys, and 10 days of age in girls. Many boys and girls with C-CAH from Sri Lanka presented late with impending adrenal crisis. Males were diagnosed later, and some possibly succumbed to C-CAH undiagnosed. These findings support including CAH in NBS programs to avert preventable childhood morbidity and mortality. [ABSTRACT FROM AUTHOR]