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1. Seasonal variation of kaurenoic acid, a hypoglycemic diterpene present in Wedelia paludosa (Acmela brasiliensis) (Asteraceae).

Author

Bresciani LF, Yunes RA, Bürger C, De Oliveira LE, Bóf KL, and Cechinel-Filho V

Subjects
Animals, Blood Glucose drug effects, Diterpenes metabolism, Glucose Tolerance Test, Glyburide pharmacology, Hyperglycemia blood, Male, Rats, Rats, Wistar, Seasons, Blood Glucose metabolism, Diterpenes analysis, Diterpenes pharmacology, Hypoglycemic Agents analysis, Hypoglycemic Agents pharmacology, Plant Extracts analysis, Wedelia chemistry
Abstract

We evaluated the variation of the concentration of kaurenoic acid (1), which is a bioactive diterpene, in leaves, flowers, stems and roots from Wedelia paludosa (Acmela brasiliensis) for different seasons using the HRGC/FID method. The results indicated that the concentration of 1 is higher in the roots and stems during the autumn. The pharmacological results suggested that kaurenoic acid is responsible, at least in part, for the hypoglycemic potential detected in this plant.

Published
2004
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