1. Bif-1 is overexpressed in hepatocellular carcinoma and correlates with shortened patient survival
- Author
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Rengen Fan, Changzhi Song, Yufeng Miao, Xiangxiang Shan, Haixin Qian, Guangzhou Wu, Wenzhang Zha, and Yan Chen
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Oncogene ,business.industry ,Cell ,fungi ,Cancer ,Cell cycle ,medicine.disease ,Molecular medicine ,medicine.anatomical_structure ,Oncology ,Hepatocellular carcinoma ,medicine ,Immunohistochemistry ,business ,Survival analysis ,Research Article - Abstract
Bax-interacting factor-1 (Bif-1) interacts with Beclin1 [the mammalian ortholog of yeast autophagy-related gene 6 (Atg6)] and affects the formation of autophagosomes during autophagy. The aim of this study was to explore Bif-1 expression and its prognostic significance in comparison with various clinicopathological predictors of survival. Bif-1 protein expression was determined by immunohistochemistry in 206 hepatocellular carcinomas. Cytoplasmic immunoreactivity was scored semi-quantitatively. The results were analyzed in correlation with various clinicopathological characteristics, including patient survival. The Chi-square test and Kaplan-Meier survival analysis were applied. The expression of Bif-1 was significantly higher in the hepatocellular cancers than in the adjacent matched non-tumor tissues (51.5 vs. 33.0%, P
- Published
- 2012