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The Karlovy Vary Massif (KVM) in northern Bohemia is a composite granite body built up of Late Variscan biotite, two-mica and lithium mica granites. We summarize the available whole-rock geochemical and petrological data and correlate them with similar information from three boreholes in the northern and southwestern parts of the Massif. The aim of the study was to determine whether various types of granites differ in their physical and chemical properties, and whether any differences in physical characteristics affect the accuracy of geophysical interpretation. In accord with the earlier studies, we distinguish two geochemically and petrophysically contrasting granite suites - the Older Intrusive Complex (OIC) and Younger Intrusive Complex (YIC). The geochemical data show that the OIC and YIC granites differ significantly in the content of most major-element oxides (like SiO2, TiO2, FeO, Fe203tot, MgO and CaO). As to physical parameters, the granites differ markedly in magnetic susceptibilities and in the contents of radioactive elements (U and Th). From gravity and magnetic data we compiled a 22 km long geophysical profile, which crosses two of the three studied boreholes. For the construction of geological model along this profile, we used the data on the petrophysical properties measured on samples from the boreholes. Densities of the individual granite types are very similar to each other and thus the distinction of the OIC and YIC granites based on gravity data is not possible. Magnetic susceptibility differs markedly for the OIC and YIC granites in the drill logs, but absolute values of magnetic susceptibilities are very low. Modelling showed that neither gravimetry nor magnetometry are suitable methods for distinguishing between the different types of granites. On the other hand, it proved that the spatial distribution of individual granite intrusions does not affect the overall interpretation of the shape, size and depth of the whole granite body. [ABSTRACT FROM AUTHOR]