1. The effects of reformulation: improved therapeutic index.
- Author
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MacDiarmid S, Sandage BW Jr, and Malhotra BK
- Subjects
- Benzilates, Chemistry, Pharmaceutical, Humans, Tolterodine Tartrate, Benzhydryl Compounds therapeutic use, Cresols therapeutic use, Mandelic Acids therapeutic use, Muscarinic Antagonists therapeutic use, Nortropanes therapeutic use, Phenylpropanolamine therapeutic use, Urinary Bladder, Overactive drug therapy
- Abstract
Antimuscarinic agents are the treatment of choice for overactive bladder syndrome. Due to the development of novel delivery systems, extended-release formulations of oxybutynin, tolterodine, and trospium chloride are now available. In addition to the convenience of once-daily dosing, the new formulations of these commonly prescribed agents have improved their therapeutic index, striking a better balance between efficacy and tolerability.
- Published
- 2008
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