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Objetive: To describe immunophenotypic features of acute leukemia cases diagnosed in the Department of Pathology Clinic in a level III Hospital in Chiclayo, Peru during the period 2010 - 2013. Materials and Methods: A secondary cross-sectional study in 116 patients diagnosed with acute leukemia in Department of Clinical Pathology in a level III Hospital in Chiclayo, Peru during the period 2010 - 2013. Information was obtained by applying a data collection sheet, based on the results of flow cytometry in patients. Results: In our study, 116 patients (62 men and 54 women) diagnosed with acute lymphoblastic leukemias (ALL) and myeloblastic (AML) were evaluated. The mean age was 27 years (SD ± 23). ALL was the most frequent with 58.62%, with predominance of LLA-B with 54.31%, and LLA-T with 4.31%. The AML represents 41.38%, with predominance of non promyelocytic AML with 33.62% and promyelocytic AML with 7.76%. The main aberrant phenotypes that corresponded to acute lymphoblastic leukemia B were: lineage infidelity (76.2%) followed by overexpression (47.6%), rare phenotypes (36.5%) and asynchronisms (7.9%). Conclusions: In the acute lymphoid leukemia T rare phenotype corresponded to 100% of cases and in promyelocytic acute myeloid leukemias 50% showed overexpression and 50% showed asynchronisms; in non promyelocytic acute leukemia the mayority of cases presented asynchronisms (51.3%), followed by overexpression (48.7%) and lineage infidelity (7.7%). [ABSTRACT FROM AUTHOR]