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A chemosensor array comprising 45 off-the-shelf colorimetric dyes, dubbed the Singapore Tongue (SGT), that is capable of discriminating different brands of bottled water and waters of different geographical attribute is described. Twelve kinds of bottled waters were tested by the SGT, and changes of absorbance spectra were analyzed by unsupervised classification methods to validate the SGT system for water analysis. All 12 bottled waters were discriminated at 1 × concentration, and SGT could distinguish the identity of samples of the waters diluted up to 100 times, except distilled waters. Following the study of 63 tap waters in different mass rapid transit stations in Singapore, two distinct clusters were observed from a principal component analysis plot, which correspond to the origin of the tap water. The successful discrimination and identification of in this study demonstrates the practical application of the SGT as a simple tool for water analysis. [ABSTRACT FROM AUTHOR]

To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the C–C bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. [ABSTRACT FROM AUTHOR]