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Fumonizini, nedavno otkriveni metaboliti plijesni Fusarium moniliforme Sheldon u inficiranom kukuruzu i drugim žitaricama, razlogom su zabrinutosti u mnogim državama. Trenutačno, čini se da su gospodarski i zdravstveni problemi uzrokovani drugim mikotsinima daleko manje značajni u usporedbi s FB, do sada najpotentnijim promotorom rasta tumora. Ovi mikotoksini imaju ulogu u pojavi leukoencefalomalacije konja (ELEM), pulmonarnog edema svinja (PPE), različitih zdravstvenih poremetnji u peradi, hepatokarcinoma štakora i moguće karcinoma jednjaka u ljudi. Također, fumonizini značajan su problem zbog proširenosti plijesni F. monilitorme, pojavljuju se u visokim količinama i jedinstvenog su načina djelovanja. Fumonizini interferiraju s biosintezom sfingolipida specifičnom inhibicijom enzima sfinganin-N-acil-transferaze što uzrokuje poremećaj u metabolizmu i prenošenju signala u stanici., Fumonisins, recently discovered metabolites of Fusarium moniliforme Sheldon, occuring naturally in infected corn and other cereals are an area of growing concern in many countries. Presently, it seems that the economic and health risk of other mycotoxins is far below the significans of potent tumor promoter fumonisin B₁. These compounds are involved in incidence of equine leukoencephalomalacia (ELEM), porcine pulmonary edema (PPE), disease problems in poultry, hepatocarcinoma in rats and possibly esophageal carcinoma (EG) in humans. Fumonisins are significant problem because F. moniliforme in corn is widespread, naturally they occur in ppm range, and their mode of action is unique. They interfere with sphingolipid biosynthesis by specifically inhibiting an enzyme sphinganine-N-acyl transferase. Because of this, the activity of secondar messanger system in the cells is affected.