Editors Contributors Chapter 1: Introduction Kazuo Kitaura and Dmitri G. Fedorov Chapter 2: Theoretical Background of the Fragment Molecular Orbital (Fmo) Method and Its Implementation in GAMESS Dmitri G. Fedorov and Kazuo Kitaura Chapter 3: Developments of FMO Methodology and Graphical User Interface in ABINIT-MP Tatsuya Nakano, Yuji Mochizuki, Akifumi Kato, Kaori Fukuzawa, Takeshi Ishikawa, Shinji Amari, Ikuo Kurisaki, and Shigenori Tanaka Chapter 4: Excited States of Photoactive Proteins by Configuration Interaction Studies Yuji Mochizuki, Tatsuya Nakano, Naoki Taguchi, and Shigenori Tanaka Chapter 5: The Fragment Molecular Orbital-Based Time-Dependent Density Functional Theory for Excited States in Large Systems Mahito Chiba, Dmitri G. Fedorov, and Kazuo Kitaura Chapter 6: FMO-MD: An Ab Initio-Based Molecular Dynamics of Large Systems Yuto Komeiji Chapter 7: Application of the FMO Method to Specific Molecular Recognition of Biomacromolecules Kaori Fukuzawa, Yuji Mochizuki, Tatsuya Nakano, and Shigenori Tanaka Chapter 8: Detailed Electronic Structure Studies Revealing the Nature of Protein-Ligand Binding Isao Nakanishi, Dmitri G. Fedorov, and Kazuo Kitaura Chapter 9: How Does the FMO Method Help in Studying Viruses and Their Binding to Receptors? Toshihiko Sawada, Tomohiro Hashimoto, Hiroaki Tokiwa, Tohru Suzuki, Hirofumi Nakano, Hideharu Ishida, Makoto Kiso, and Yasuo Suzuki Chapter 10: FMO as a Tool for Structure-Based Drug Design Tomonaga Ozawa, Kosuke Okazaki, and Motohiro Nishio Chapter 11: Modeling a Protein Environment in an Enzymatic Catalysis: A Case Study of the Chorismate Mutase Reaction Toyokazu Ishida Index