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Overview of Adaptive Design Methods in Clinical Trials, Annpey Pong and Shein-Chung Chow Fundamental Theory of Adaptive Designs with Unplanned Design Change in Clinical Trials with Blinded Data, Qing Liu and George Y.H. Chi Bayesian Approach for Adaptive Design, Guosheng Yin and Ying Yuan The Impact of Protocol Amendments in Adaptive Trial Designs, Shein-Chung Chow and Annpey Pong From Group Sequential to Adaptive Designs, Christopher Jennison and Bruce W. Turnbull Determining Sample Size for Classical Designs, Simon Kirby and Christy Chuang-Stein Sample Size Reestimation Design with Applications in Clinical Trials, Lu Cui and Xiaoru Wu Adaptive Interim Analyses in Clinical Trials, Gernot Wassmer Classical Dose-Finding Trial, Naitee Ting Improving Dose-Finding: A Philosophic View, Carl-Fredrik Burman, Frank Miller, and Kiat Wee Wong Adaptive Dose-Ranging Studies, Marc Vandemeulebroecke, Frank Bretz, Jose Pinheiro, and Bjorn Bornkamp Seamless Phase I/II Designs, Vladimir Dragalin Phase II/III Seamless Designs, Jeff Maca Sample Size Estimation/Allocation for Two-Stage Seamless Adaptive Trial Designs, Shein-Chung Chow and Annpey Pong Optimal Response-Adaptive Randomization for Clinical Trials, Lanju Zhang and William Rosenberger Hypothesis-Adaptive Design, Gerhard Hommel Treatment Adaptive Allocations in Randomized Clinical Trials: An Overview, Atanu Biswas and Rahul Bhattacharya Integration of Predictive Biomarker Diagnostics into Clinical Trials for New Drug Development, Richard Simon Clinical Strategy for Study Endpoint Selection, Siu Keung Tse, Shein-Chung Chow, and Qingshu Lu Adaptive Infrastructure, Bill Byrom, Damian McEntegart, and Graham Nicholls Independent Data Monitoring Committees, Steven Snapinn and Qi Jiang Targeted Clinical Trials, Jen-Pei Liu Functional Genome-Wide Association Studies of Longitudinal Traits, Jiangtao Luo, Arthur Berg, Kwangmi Ahn, Kiranmoy Das, Jiahan Li, Zhong Wang, Yao Li, and Rongling Wu Adaptive Trial Simulation, Mark Chang Efficiency of Adaptive Designs, Nigel Stallard and Tim Friede Cases Studies in Adaptive Design, Ning Li, Yonghong Gao, and Shiowjen Lee Good Practices for Adaptive Clinical Trials, Paul Gallo Index