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Objectives: we evaluated the association of daily pollutants' concentrations with daily hospital admissions for respiratory causes in children residents in Pisa during 1998-2002. We compared the results obtained with two methods of statistical analyses. A total of 657 children under ten years and admitted to local hospitals for respiratory diseases (ICD 9: 460-469, 480- 519) were included in the study., Design: both time-series and case-crossover analysis were applied, controlling for temperature, holidays, influenza epidemics,rain and relative humidity. Pollutants' effects are expressed as percentage increase (and 95% CI) of hospital admissions for an increase of 10 μg/m³ of pollutants (1 mg/m³ for CO)., Results: with both analyses, children's hospital admissions for respiratory conditions were significantly associated to increasing daily levels of PM10 and CO at different time lags, while no association was found for NO₂ and O₃. In the case-crossover analysis, for a daily increase of 10 μg/m³ in PM10, a significant increment of 8.5% (CI 95% 0.02; 17.6) in children respiratory admissions was observed at lag 0-3. Results were stronger for males and during the warm season. A 1 mg/m³ increment in daily CO levels was associated with an increase of respiratory admissions at lag 0 (20.2%, CI 95% 5.3; 37.2) and at all cumulative lags: the maximum value was observed at lag 0-3 (32.6%, CI 95%8.3; 62.2). Time series analyses provides similar results, although the estimates were lower than with the other method, in terms of percentage increment and length of confidence intervals., Conclusions: this study indicates adverse effects of air pollution on respiratory health of children living in urban environment. The results of both analyses were consistent.

Objectives: Italy is one of the industrialized countries with the highest mortality from road accidents. The mortality index of road accidents in Piemonte is one of the highest in Italy. This study assesses the main factors affecting the mortality among drivers., Design: Police reports of 95,944 road traffic accidents occurred between 1999 and 2004 in Piemonte, involving 178,230 drivers, were analysed. Multivariate logistic regression models were used to estimate the association of drivers' and accidents' characteristics with mortality among drivers. Analyses were stratified for car, truck and two-wheel vehicle drivers., Results: Mortality is affected by age and gender. In addition, the main risk factors are night-time, extra-urban roads, mountain areas and two wheel vehicles. The drivers license penalty point regulation law introduced in Italy on July 2003 seems to have had a protective effect on mortality during the early months of application., Conclusions: Official data are useful for estimating potential determinants of road injuries' outcome. Factors affecting the occurrence of accidents are not necessarily predictors of outcome severity. An effective prevention policy of frequency of accidents, mortality and disability should be based on drivers'safety education, structural interventions, targeted road controls and law enforcement.