1. Níveis circulantes da lectina ligadora de manose (MBL) na degeneração macular relacionada à idade
- Author
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Iara Messias-Reason, Fernando Morandini Pradella, Diego Schebelski, Mário Teruo Sato, Renato Nisihara, Marcelo Pires, Alexandre Achille Grandinetti, and Sergio Brillinger Novello
- Subjects
Male ,medicine.medical_specialty ,Fluoroimmunoassay ,Inflammation ,Drusen ,Mannose-Binding Lectin ,Gastroenterology ,Statistics, Nonparametric ,Retina ,Macular Degeneration ,lcsh:Ophthalmology ,Reference Values ,Risk Factors ,Age related ,Internal medicine ,medicine ,Humans ,In patient ,Degeneração macular relacionada à idade ,Drusas ,Aged ,Mannan-binding lectin ,Aged, 80 and over ,Lectina de ligação a manose ,Mannose-binding lectin ,biology ,business.industry ,Age-related macular degeneration ,Age Factors ,Lectin ,Immunoregulation ,General Medicine ,Middle Aged ,Macular degeneration ,medicine.disease ,Complement system ,Ophthalmology ,Inflamação ,lcsh:RE1-994 ,Case-Control Studies ,Imunoregulação ,biology.protein ,Female ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
Purpose: To assess whether the serum levels of mannose-binding lectin of the lectin complement pathway are associated with age-related macular degeneration. Methods: Patients with age-related macular degeneration and age-matched controls underwent full ophthalmologic examination and optical coherence tomography. Using a time-resolved immunofluorometric assay, blood samples were evaluated to determine the serum mannose-binding lectin levels. Results: A total of 136 individuals were evaluated, including 68 patients with age-related macular degeneration (34 exudative and 34 nonexudative) and 68 age-matched controls. The median mannose-binding lectin level was 608 ng/mL (range, 30-3,415 ng/mL) in patients with age-related macular degeneration and 739 ng/mL (range, 30-6,039 ng/mL) in controls, with no difference between the groups. Additionally, the median mannose-binding lectin level was 476 ng/mL (range, 30-3,415 ng/mL) in exudative cases and 692 ng/mL (range, 30-2,587 ng/mL) in nonexudative cases. Conclusions: Serum mannose-binding lectin levels were not associated with age-related macular degeneration or with the exudative and nonexudative forms of the disease. RESUMO Objetivos: Avaliar se as concentrações séricas da lectina ligante de manose da via das lectinas do sistema complemento estão associadas à degeneração macular relacionada à idade. Métodos: Pacientes com degeneração macular relacionada à idade a controles pareados realizaram exame oftalmológico completo e imagens de tomografia de coerência óptica. As concentrações de lectina ligante de manose foram aferidas em amostras de sangue pelo método "time-resolved Immunofluorometric assay". Resultados: Um total de 136 indivíduos foram avaliados incluindo 68 com degeneração macular relacionada à idade (34 exsudativa e 34 não-exsudativa) e 68 controles. Concentrações medianas de lectina ligante de ma-nose foram 608 ng/mL (30-3,415 ng/mL) nos casos e 739 ng/mL (30-6,039 ng/mL) nos controles, não havendo diferença entre os grupos. Comparando degeneração macular relacionada a idade exsudativa (mediana de lectina ligante de manose 476 ng/mL; 30-3,415 ng/mL) e não-exsudativa (692 ng/mL; 30-2,587 ng/mL) também não apresentaram diferença. Conclusões: Concentrações séricas de lectina ligante de manose não estão relacionadas à degeneração macular relacionada a idade ou às formas exsudativa e não-exsudativa.