1. Use of avian bornavirus isolates to induce proventricular dilatation disease in conures
- Author
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Negin Mirhosseini, Sanjay M. Reddy, Sharman Hoppes, H. L. Shivaprasad, Itamar Villanueva, Ian Tizard, Paulette F. Suchodolski, Thomas Briese, Patricia L. Gray, Susan Payne, and Kirsi S. Honkavuori
- Subjects
Microbiology (medical) ,Pathology ,medicine.medical_specialty ,animal structures ,proventriculus ,Epidemiology ,viruses ,viral encephalitis ,lcsh:Medicine ,lcsh:Infectious and parasitic diseases ,Pathogenesis ,Duck embryo ,Tissue culture ,Proventricular dilatation disease ,Avian bornavirus ,Virology ,medicine ,Animals ,lcsh:RC109-216 ,Cells, Cultured ,research ,biology ,Bird Diseases ,Viral encephalitis ,lcsh:R ,virus diseases ,Proventriculus ,Fibroblasts ,biology.organism_classification ,medicine.disease ,humanities ,Ducks ,Infectious Diseases ,Bornaviridae ,Conure ,parrots ,Dilatation, Pathologic - Abstract
The fulfillment of Koch’s postulates shows that the virus causes proventricular dilatation disease in parrots., Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). We successfully isolated and characterized ABV from the brains of 8 birds with confirmed PDD. One isolate was passed 6 times in duck embryo fibroblasts, and the infected cells were then injected intramuscularly into 2 healthy Patagonian conures (Cyanoliseus patagonis). Clinical PDD developed in both birds by 66 days postinfection. PDD was confirmed by necropsy and histopathologic examination. Reverse transcription–PCR showed that the inoculated ABV was in the brains of the 2 infected birds. A control bird that received uninfected tissue culture cells remained healthy until it was euthanized at 77 days. Necropsy and histopathologic examinations showed no abnormalities; PCR did not indicate ABV in its brain tissues.
- Published
- 2010
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