1. The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction.
- Author
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Sachser RM, Crestani AP, Quillfeldt JA, Mello E Souza T, and de Oliveira Alvares L
- Subjects
- Animals, Cannabinoid Receptor Agonists pharmacology, Cannabinoid Receptor Antagonists pharmacology, Catheters, Indwelling, Cerebral Cortex drug effects, Conditioning, Psychological drug effects, Conditioning, Psychological physiology, Cyclohexanols pharmacology, Extinction, Psychological drug effects, Fear drug effects, Male, Memory Consolidation drug effects, Piperidines pharmacology, Pyrazoles pharmacology, Rats, Wistar, Receptor, Cannabinoid, CB1 agonists, Receptor, Cannabinoid, CB1 antagonists & inhibitors, Cerebral Cortex metabolism, Extinction, Psychological physiology, Fear physiology, Memory Consolidation physiology, Receptor, Cannabinoid, CB1 metabolism
- Abstract
Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-RSC infusion of the CB1R antagonist AM251 impaired, and the agonist CP55940 improved, long-term memory consolidation. Additionally, a post-reactivation infusion of AM251 enhanced memory reconsolidation, while CP55940 had the opposite effect. Finally, AM251 blocked extinction, whereas CP55940 facilitated it and maintained memory extinguished over time. Altogether, our data strongly suggest that the cannabinoid system of the RSC modulates emotional memory., (© 2015 Sachser et al.; Published by Cold Spring Harbor Laboratory Press.)
- Published
- 2015
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