1. Analyses of deep mammalian sequence alignment and constraint predictions for 1% of the human genome
- Author
-
Margulies, Elliott H., Schwartz, Ariel S., Loytynoja, Ari, Whelan, Simon, Pardi, Fabio, Taylor, James, Nikolaev, Sergey, Montoya-Burgos, Juan I., Minmei Hou, Dewey, Colin N., Siepel, Adam, Birney, Ewan, Keefe, Damian, Cooper, Gregory M., Asimenos, George, Thomas, Daryl J., Massingham, Tim, Ureta-Vidal, Abel, Paten, Benedict; Stone, Eric A., Bickel, Peter, Mullikin, James C., Holmes, Ian, Rosenbloom, Kate R., Brown, James B., Goldman, Nick, Hardison, Ross, Miller, Webb, Haussler, David, Antonarakis, Stylianos E., Batzoglou, Serafim, Kent, W.James, Pachter, Lior, Green, Eric D., and Sidow, Arend
- Subjects
Mammals -- Genetic aspects ,Nucleotide sequence -- Analysis ,Biological diversity -- Analysis ,Health - Abstract
The sequence analyses of functional elements involving sequence generation, alignment and evolutionary constraint of 23 mammalian species are carried out using quantitative and qualitative methods. The constraint regions and the elements are found to be nonoverlapping.
- Published
- 2007