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Your search keyword '"Vaught, Lauren A."' showing total 13 results
Start Over Author "Vaught, Lauren A." Publisher cold spring harbor laboratory
13 results on '"Vaught, Lauren A."'

2. New semi-automated tool for the quantitation of MR imaging to estimate in vivo muscle disease severity in mice

Author

Waters, Emily A., Haney, Chad R., Vaught, Lauren. A, McNally, Elizabeth M., and Demonbreun, Alexis R.

Subjects
Article
Abstract

The pathology in Duchenne muscular dystrophy (DMD) is characterized by degenerating muscle fibers, inflammation, fibro-fatty infiltrate, and edema, and these pathological processes replace normal healthy muscle tissue. Themdxmouse model is one of the most commonly used preclinical models to study DMD. Mounting evidence has emerged illustrating that muscle disease progression varies considerably inmdxmice, with inter-animal differences as well as intra-muscular differences in pathology in individualmdxmice. This variation is important to consider when conducting assessments of drug efficacy and in longitudinal studies. Magnetic resonance imaging (MRI) is a non-invasive method that can be used qualitatively or quantitatively to measure muscle disease progression in the clinic and in preclinical models. Although MR imaging is highly sensitive, image acquisition and analysis can be time intensive. The purpose of this study was to develop a semi-automated muscle segmentation and quantitation pipeline that can quickly and accurately estimate muscle disease severity in mice. Herein, we show that the newly developed segmentation tool accurately divides muscle. We show that measures of skew and interdecile range based on segmentation sufficiently estimate muscle disease severity in healthy wildtype and diseasedmdxmice. Moreover, the semi-automated pipeline reduced analysis time by nearly 10-fold. Use of this rapid, non-invasive, semi-automated MR imaging and analysis pipeline has the potential to transform preclinical studies, allowing for pre-screening of dystrophic mice prior to study enrollment to ensure more uniform muscle disease pathology across treatment groups, improving study outcomes.

Published
2023
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3. Myoscaffolds demonstrate differential matrix components across muscular dystrophies

Author

Long, Ashlee M., primary, Kwon, Jason, additional, Reiser, Nina. L., additional, Vaught, Lauren. A, additional, O’Brien, Joseph G., additional, Page, Patrick G.T., additional, Lee, GaHyun, additional, Hadhazy, Michele, additional, Reynolds, Joseph C., additional, Crosbie, Rachelle H., additional, McNally, Elizabeth M., additional, and Demonbreun, Alexis R., additional

Published
2022
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6. Low levels of protective humoral immunity following mild or asymptomatic infection with SARS-CoV-2 in a community-based serological study

Author

McDade, Thomas W., primary, Sancilio, Amelia, additional, D’Aquila, Richard, additional, Mustanski, Brian, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Velez, Matthew P., additional, Hsieh, Ryan R., additional, Ryan, Daniel T., additional, Saber, Rana, additional, McNally, Elizabeth M., additional, and Demonbreun, Alexis R., additional

Published
2021
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7. Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults

Author

Schrock, Joshua M., primary, Ryan, Daniel T., additional, Saber, Rana, additional, Benbow, Nanette, additional, Vaught, Lauren A., additional, Reiser, Nina, additional, Velez, Matthew P., additional, Hsieh, Ryan, additional, Newcomb, Michael, additional, Demonbreun, Alexis R., additional, Mustanski, Brian, additional, McNally, Elizabeth M., additional, D’Aquila, Richard, additional, and McDade, Thomas W., additional

Published
2021
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8. Comparison of IgG and neutralizing antibody responses after one or two doses of COVID-19 mRNA vaccine in previously infected and uninfected persons

Author

Demonbreun, Alexis R., primary, Sancilio, Amelia, additional, Velez, Matt E., additional, Ryan, Daniel T., additional, Saber, Rana, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Hsieh, Ryan R., additional, D’Aquila, Richard T., additional, Mustanski, Brian, additional, McNally, Elizabeth M., additional, and McDade, Thomas W., additional

Published
2021
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9. Geographic disparities in COVID-19 case rates are not reflected in seropositivity rates using a neighborhood survey in Chicago

Author

Mustanski, Brian, primary, Saber, Rana, additional, Ryan, Daniel T., additional, Benbow, Nanette, additional, Madkins, Krystal, additional, Hayford, Christina, additional, Newcomb, Michael E., additional, Schrock, Joshua M., additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Velez, Matthew P., additional, Hsieh, Ryan, additional, Demonbreun, Alexis R., additional, D’Aquila, Richard, additional, McNally, Elizabeth M., additional, and McDade, Thomas W., additional

Published
2021
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10. Symptoms of COVID-19 infection and magnitude of antibody response in a large community-based study

Author

McDade, Thomas W., primary, Schrock, Joshua M., additional, D’Aquila, Richard, additional, Mustanski, Brian, additional, Benbow, Nanette, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Velez, Matt E., additional, Hsieh, Ryan R., additional, Ryan, Daniel T., additional, Saber, Rana, additional, McNally, Elizabeth M., additional, and Demonbreun, Alexis R., additional

Published
2021
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11. Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure

Author

Demonbreun, Alexis R., primary, McDade, Thomas W., additional, Pesce, Lorenzo, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Bogdanovic, Elena, additional, Velez, Matthew P., additional, Hsieh, Ryan R., additional, Simons, Lacy M., additional, Saber, Rana, additional, Ryan, Daniel T., additional, Ison, Michael G., additional, Hultquist, Judd F., additional, Wilkins, John T., additional, D’Aquila, Richard T., additional, Mustanski, Brian, additional, and McNally, Elizabeth M., additional

Published
2020
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12. High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay

Author

McDade, Thomas W., primary, McNally, Elizabeth M., additional, Zelikovich, Aaron S., additional, D’Aquila, Richard, additional, Mustanski, Brian, additional, Miller, Aaron, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Bogdanovic, Elena, additional, Fallon, Katherine S., additional, and Demonbreun, Alexis R., additional

Published
2020
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13. Enzyme immunoassay for SARS-CoV-2 antibodies in dried blood spot samples: A minimally-invasive approach to facilitate community- and population-based screening

Author

McDade, Thomas W., primary, McNally, Elizabeth M., additional, D’Aquila, Richard, additional, Mustanski, Brian, additional, Miller, Aaron, additional, Vaught, Lauren A., additional, Reiser, Nina L., additional, Bogdanovic, Elena, additional, Zelikovich, Aaron S., additional, and Demonbreun, Alexis R., additional

Published
2020
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