1. mRNA challenge predicts brain cancer immunogenicity and response to checkpoint inhibitors
- Author
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Paul Castillo, Elizabeth Ogando-Rivas, Hilary Geffrard, Alfonso Pepe, Ruixuan Liu, Duy T Nguyen, Diego I Pedro, Dingpeng Zhang, Anna DeVries, Sadeem Qdaisat, Aida Karachi, Maryam Rahman, Frances Weidert, Rowan Milner, Jianping Huang, Natalie L. Silver, John Ligon, Derek Li, Ji-Hyun Lee, Sheila Carrera-Justiz, Duane A Mitchell, Hector Mendez-Gomez, W Gregory Sawyer, and Elias J Sayour
- Subjects
Article - Abstract
To prospectively determine whether brain tumors will respond to immune checkpoint inhibitors (ICIs), we developed a novel mRNA vaccine as a viral mimic to elucidate cytokine release from brain cancer cells in vitro. Our results indicate that cytokine signatures following mRNA challenge differ substantially from ICI responsive versus non-responsive murine tumors. These findings allow for creation of a diagnostic assay to quickly assess brain tumor immunogenicity, allowing for informed treatment with ICI or lack thereof in poorly immunogenic settings.
- Published
- 2023