25 results on '"Raffield, Laura M"'
Search Results
2. The expected polygenic risk score (ePRS) framework: an equitable metric for quantifying polygenetic risk via modeling of ancestral makeup
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Huang, Yu-Jyun, primary, Kurniansyah, Nuzulul, additional, Goodman, Matthew O, additional, Spitzer, Brian W, additional, Wang, Jiongming, additional, Stilp, Adrienne M, additional, Laurie, Cecelia, additional, de Vries, Paul S, additional, Chen, Han, additional, Min, Yuan-I, additional, Sims, Mario, additional, Peloso, Gina M, additional, Guo, Xiuqing, additional, Bis, Joshua C, additional, Brody, Jennifer A, additional, Raffield, Laura M, additional, Smith, Jennifer A, additional, Zhao, Wei, additional, Rotter, Jerome I, additional, Rich, Stephen S, additional, Redline, Susan, additional, Fornage, Myriam, additional, Kaplan, Robert, additional, Franceschini, Nora, additional, Levy, Daniel, additional, Morrison, Alanna C, additional, Boerwinkle, Eric, additional, Smith, Nicholas L, additional, Kooperberg, Charles, additional, Psaty, Bruce M, additional, Zoellner, Sebastian, additional, and Sofer, Tamar, additional
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- 2024
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3. Determinants of mosaic chromosomal alteration fitness
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Pershad, Yash, primary, Mack, Taralynn, additional, Poisner, Hannah, additional, Jakubek, Yasminka A, additional, Stilp, Adrienne M, additional, Mitchell, Braxton D, additional, Lewis, Joshua P, additional, Boerwinkle, Eric, additional, Loos, Ruth J, additional, Chami, Nathalie, additional, Wang, Zhe, additional, Barnes, Kathleen, additional, Pankratz, Nathan, additional, Fornage, Myriam, additional, Redline, Susan, additional, Psaty, Bruce M, additional, Bis, Joshua C, additional, Shojaie, Ali, additional, Silverman, Edwin K, additional, Cho, Michael H, additional, Yun, Jeong, additional, DeMeo, Dawn, additional, Levy, Daniel, additional, Johnson, Andrew, additional, Mathias, Rasika, additional, Taub, Margaret, additional, Arnett, Donna, additional, North, Kari, additional, Raffield, Laura M, additional, Carson, April, additional, Doyle, Margaret F, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Guo, Xiuqing, additional, Cox, Nancy, additional, Roden, Dan M, additional, Franceschini, Nora, additional, Desai, Pinkal, additional, Reiner, Alex, additional, Auer, Paul L, additional, Scheet, Paul, additional, Jaiswal, Siddhartha, additional, Weinstock, Joshua S, additional, and Bick, Alexander G, additional
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- 2023
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4. Carriers of rare damaging CCR2 genetic variants are at lower risk of atherosclerotic disease
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Georgakis, Marios K, primary, Malik, Rainer, additional, Hasbani, Natalie R, additional, Shakt, Gabrielle, additional, Morrison, Alanna, additional, Tsao, Noah L, additional, Judy, Renae, additional, Mitchell, Braxton D, additional, Xu, Huichun, additional, Montasser, May E, additional, Do, Ron, additional, Kenny, Eimear, additional, Loos, Ruth J.F., additional, Terry, James G, additional, Carr, John Jeffrey, additional, Bis, Joshua C., additional, Psaty, Bruce M., additional, Longstreth, W T, additional, Young, Kendra, additional, Lutz, Sharon M, additional, Cho, Michael, additional, Broome, Jai, additional, Khan, Alyna T, additional, Wang, Fei Fei, additional, Heard-Costa, Nancy, additional, Seshadri, Sudha, additional, Ramachandran, Vasan, additional, Palmer, Nicholette D., additional, Freedman, Barry I, additional, Bowden, Donald W, additional, Yanek, Lisa R, additional, Kral, Brian G, additional, Becker, Lewis C, additional, Peyser, Patricia A, additional, Bielak, Lawrence F, additional, Ammous, Farah, additional, Carson, April P., additional, Hall, Michael E, additional, Raffield, Laura M, additional, Rich, Steve, additional, Post, Wendy, additional, Tracy, Russell, additional, Taylor, Kent, additional, Guo, Xiuqing, additional, Mahaney, Michael, additional, Curran, Joanne E., additional, Blangero, John, additional, Clarke, Shoa L., additional, Haessler, Jeffrey, additional, Hu, Yao, additional, Assimes, Themistocles L, additional, Kooperberg, Charles, additional, Damrauer, Scott M., additional, Rotter, Jerome, additional, de Vries, Paul S, additional, and Dichgans, Martin, additional
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- 2023
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5. The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes
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Ha, Edward T., primary, Taylor, Kent D., additional, Raffield, Laura M, additional, Briggs, William M, additional, Yee, Aaron, additional, Elemento, Olivier, additional, Parikh, Manish A., additional, Peterson, Stephen J, additional, Frishman, William, additional, Gerszten, Robert E, additional, Wilson, James G., additional, Kelsey, Karl T., additional, Tahir, Usman A., additional, Reiner, Alexander P., additional, Auer, Paul, additional, Seeman, Teresa E., additional, Rich, Stephen S. S., additional, Carson, April P., additional, Post, Wendy S., additional, Rotter, Jerome I. I., additional, and Aronow, Wilbert S., additional
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- 2023
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6. Gene Expression and Splicing QTL Analysis of Blood Cells in African American Participants from the Jackson Heart Study
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Wen, Jia, primary, Sun, Quan, additional, Huang, Le, additional, Zhou, Lingbo, additional, Doyle, Margaret F., additional, Ekunwe, Lynette, additional, Olson, Nels C., additional, Reiner, Alexander P., additional, Li, Yun, additional, and Raffield, Laura M., additional
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- 2023
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7. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
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Huffman, Jennifer E, Nicolas, Jayna, Hahn, Julie, Heath, Adam S, Raffield, Laura M, Yanek, Lisa R, Brody, Jennifer A, Thibord, Florian, Almasy, Laura, Bartz, Traci M, Bielak, Lawrence F., Bowler, Russell P, Carrasquilla, Germán D, Chasman, Daniel I, Chen, Ming-Huei, Emmert, David B, Ghanbari, Mohsen, Haessle, Jeffery, Hottenga, Jouke-Jan, Kleber, Marcus E, Le, Ngoc-Quynh, Lee, Jiwon, Lewis, Joshua P, Li-Gao, Ruifang, Luan, Jian’an, Malmberg, Anni, Mangino, Massimo, Marioni, Riccardo E, Martinez-Perez, Angel, Pankratz, Nathan, Polasek, Ozren, Richmond, Anne, Rodriguez, Benjamin AT, Rotter, Jerome I, Steri, Maristella, Suchon, Pierre, Trompet, Stella, Weiss, Stefan, Zare, Marjan, Auer, Paul, Cho, Michael H, Christofidou, Paraskevi, Davies, Gail, de Geus, Eco, Deleuze, Jean-François, Delgado, Graciela E, Ekunwe, Lynette, Faraday, Nauder, Gögele, Martin, Greinacher, Andreas, He, Gao, Howard, Tom, Joshi, Peter K, Kilpeläinen, Tuomas O, Lahti, Jari, Linneberg, Allan, Naitza, Silvia, Noordam, Raymond, Paüls-Vergés, Ferran, Rich, Stephen S, Rosendaal, Frits R, Rudan, Igor, Ryan, Kathleen A, Souto, Juan Carlos, van Rooij, Frank JA, Wang, Heming, Zhao, Wei, Becker, Lewis C, Beswick, Andrew, Brown, Michael R, Cade, Brian E, Campbell, Harry, Cho, Kelly, Crapo, James D, Curran, Joanne E, de Maat, Moniek PM, Doyle, Margaret, Elliott, Paul, Floyd, James S, Fuchsberger, Christian, Grarup, Niels, Guo, Xiuqing, Harris, Sarah E, Hou, Lifang, Kolcic, Ivana, Kooperberg, Charles, Menni, Cristina, Nauck, Matthias, O’Connell, Jeffrey R, Orrù, Valeria, Psaty, Bruce M, Räikkönen, Katri, Smith, Jennifer A, Soria, Jose Manuel, Stott, David J, van Hylckama Vlieg, Astrid, Watkins, Hugh, Willemsen, Gonneke, Wilson, Peter, Ben-Shlomo, Yoav, Blangero, John, Boomsma, Dorret, Cox, Simon R, Dehghan, Abbas, Eriksson, Johan G, Fiorillo, Edoardo, Fornage, Myriam, Hansen, Torben, Hayward, Caroline, Ikram, M. Arfan, Jukema, J Wouter, Kardia, Sharon LR, Lange, Leslie A, März, Winfried, Mathias, Rasika A, Mitchell, Braxton D, Mook-Kanamori, Dennis O, Morange, Pierre-Emmanuel, Pedersen, Oluf, Pramstaller, Peter P, Redline, Susan, Reiner, Alexander, Ridker, Paul M, Silverman, Edwin K, Spector, Tim D, Völker, Uwe, Wareham, Nick, Wilson, James F, Yao, Jie, Trégouët, David-Alexandre, Johnson, Andrew D, Wolberg, Alisa S, de Vries, Paul S, Sabater-Lleal, Maria, Morrison, Alanna C, and Smith, Nicholas L
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Article - Abstract
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole genome sequencing (WGS) data provides better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analyzed WGS data from the NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program (n=32,572), with array-based genotype data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (n=131,340) imputed to the TOPMed or Haplotype Reference Consortium panel. We identified 18 loci that have not been identified in prior genetic studies of fibrinogen. Of these, four are driven by common variants of small effect with reported MAF at least 10% higher in African populations. Three ( SERPINA1, ZFP36L2 , and TLR10) signals contain predicted deleterious missense variants. Two loci, SOCS3 and HPN , each harbor two conditionally distinct, non-coding variants. The gene region encoding the protein chain subunits ( FGG;FGB;FGA ), contains 7 distinct signals, including one novel signal driven by rs28577061, a variant common (MAF=0.180) in African reference panels but extremely rare (MAF=0.008) in Europeans. Through phenome-wide association studies in the VA Million Veteran Program, we found associations between fibrinogen polygenic risk scores and thrombotic and inflammatory disease phenotypes, including an association with gout. Our findings demonstrate the utility of WGS to augment genetic discovery in diverse populations and offer new insights for putative mechanisms of fibrinogen regulation. KEY POINTS: Largest and most diverse genetic study of plasma fibrinogen identifies 54 regions (18 novel), housing 69 conditionally distinct variants (20 novel). Sufficient power achieved to identify signal driven by African population variant. Links to (1) liver enzyme, blood cell and lipid genetic signals, (2) liver regulatory elements, and (3) thrombotic and inflammatory disease.
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- 2023
8. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
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Suzuki, Ken, Hatzikotoulas, Konstantinos, Southam, Lorraine, Taylor, Henry J., Yin, Xianyong, Lorenz, Kim M., Mandla, Ravi, Huerta-Chagoya, Alicia, Rayner, Nigel W., Bocher, Ozvan, Ana Luiza de, S. V. Arruda, Sonehara, Kyuto, Namba, Shinichi, Lee, Simon S. K., Preuss, Michael H., Petty, Lauren E., Schroeder, Philip, Vanderwerff, Brett, Kals, Mart, Bragg, Fiona, Lin, Kuang, Guo, Xiuqing, Zhang, Weihua, Yao, Jie, Kim, Young Jin, Graff, Mariaelisa, Takeuchi, Fumihiko, Nano, Jana, Lamri, Amel, Nakatochi, Masahiro, Moon, Sanghoon, Scott, Robert A., Cook, James P., Lee, Jung-Jin, Pan, Ian, Taliun, Daniel, Parra, Esteban J., Chai, Jin-Fang, Bielak, Lawrence F., Tabara, Yasuharu, Hai, Yang, Thorleifsson, Gudmar, Grarup, Niels, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloé, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Kwak, Soo-Heon, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Nongmaithem, Suraj S., Noordam, Raymond, Lim, Victor J. Y., Tam, Claudia H. T., Joo, Yoonjung Yoonie, Chen, Chien-Hsiun, Raffield, Laura M., Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R., Chen, Guanjie, Brody, Jennifer A., Kabagambe, Edmond, An, Ping, Xiang, Anny H., Choi, Hyeok Sun, Cade, Brian E., Tan, Jingyi, Alaine Broadaway, K., Williamson, Alice, Kamali, Zoha, Cui, Jinrui, Adair, Linda S., Adeyemo, Adebowale, Aguilar-Salinas, Carlos A., Ahluwalia, Tarunveer S., Anand, Sonia S., Bertoni, Alain, Bork-Jensen, Jette, Brandslund, Ivan, Buchanan, Thomas A., Burant, Charles F., Butterworth, Adam S., Canouil, Mickaël, Chan, Juliana C. N., Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Cushman, Mary, Danesh, John, Das, Swapan K., Janaka de Silva, H., Dedoussis, George, Dimitrov, Latchezar, Doumatey, Ayo P., Du, Shufa, Duan, Qing, Eckardt, Kai-Uwe, Emery, Leslie S., Evans, Daniel S., Evans, Michele K., Fischer, Krista, Floyd, James S., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Freedman, Barry I., Genter, Pauline, Gerstein, Hertzel C., Giedraitis, Vilmantas, González-Villalpando, Clicerio, González-Villalpando, Maria Elena, Gordon-Larsen, Penny, Gross, Myron, Guare, Lindsay A., Hackinger, Sophie, Han, Sohee, Hattersley, Andrew T., Herder, Christian, Horikoshi, Momoko, Howard, Annie-Green, Hsueh, Willa, Huang, Mengna, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Ikram, Mohammad Arfan, Ingelsson, Martin, Islam, Md. Tariqul, Isono, Masato, Jang, Hye-Mi, Jasmine, Farzana, Jiang, Guozhi, Jonas, Jost B., Jørgensen, Torben, Kandeel, Fouad R., Kasturiratne, Anuradhani, Katsuya, Tomohiro, Kaur, Varinderpal, Kawaguchi, Takahisa, Keaton, Jacob M., Kho, Abel N., Khor, Chiea-Chuen, Kibriya, Muhammad G., Kim, Duk-Hwan, Kronenberg, Florian, Kuusisto, Johanna, Läll, Kristi, Lange, Leslie A., Lee, Kyung Min, Lee, Myung-Shik, Lee, Nanette R., Leong, Aaron, Li, Liming, Li, Yun, Li-Gao, Ruifang, Lithgart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Liu, Ching-Ti, Liu, Jianjun, Locke, Adam E., Louie, Tin, Luan, Jian’an, Luk, Andrea O., Luo, Xi, Lv, Jun, Lynch, Julie A., Lyssenko, Valeriya, Maeda, Shiro, Mamakou, Vasiliki, Mansuri, Sohail Rafik, Matsuda, Koichi, Meitinger, Thomas, Metspalu, Andres, Mo, Huan, Morris, Andrew D., Nadler, Jerry L., Nalls, Michael A., Nayak, Uma, Ntalla, Ioanna, Okada, Yukinori, Orozco, Lorena, Patel, Sanjay R., Patil, Snehal, Pei, Pei, Pereira, Mark A, Peters, Annette, Pirie, Fraser J., Polikowsky, Hannah G., Porneala, Bianca, Prasad, Gauri, Rasmussen-Torvik, Laura J., Reiner, Alexander P., Roden, Michael, Rohde, Rebecca, Roll, Katheryn, Sabanayagam, Charumathi, Sandow, Kevin, Sankareswaran, Alagu, Sattar, Naveed, Schönherr, Sebastian, Shahriar, Mohammad, Shen, Botong, Shi, Jinxiu, Shin, Dong Mun, Shojima, Nobuhiro, Smith, Jennifer A., So, Wing Yee, Stančáková, Alena, Steinthorsdottir, Valgerdur, Stilp, Adrienne M., Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorsteinsdottir, Unnur, Tomlinson, Brian, Tran, Tam C., Tsai, Fuu-Jen, Tuomilehto, Jaakko, Tusie-Luna, Teresa, Udler, Miriam S., Valladares-Salgado, Adan, van Dam, Rob M., van Klinken, Jan B., Varma, Rohit, Wacher-Rodarte, Niels, Wheeler, Eleanor, Wickremasinghe, Ananda R., van Dijk, Ko Willems, Witte, Daniel R., Yajnik, Chittaranjan S., Yamamoto, Ken, Yamamoto, Kenichi, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Yusuf, Salim, Zawistowski, Matthew, Zhang, Liang, Zheng, Wei, Project, Biobank Japan, BioBank, Penn Medicine, Center, Regeneron Genetics, Consortium, eMERGE, Raffel, Leslie J, Igase, Michiya, Ipp, Eli, Redline, Susan, Cho, Yoon Shin, Lind, Lars, Province, Michael A., Fornage, Myriam, Hanis, Craig L., Ingelsson, Erik, Zonderman, Alan B., Psaty, Bruce M., Wang, Ya-Xing, Rotimi, Charles N., Becker, Diane M., Matsuda, Fumihiko, Liu, Yongmei, Yokota, Mitsuhiro, Kardia, Sharon L. R., Peyser, Patricia A., Pankow, James S., Engert, James C., Bonnefond, Amélie, Froguel, Philippe, Wilson, James G., Sheu, Wayne H. H., Wu, Jer-Yuarn, Geoffrey Hayes, M., Ma, Ronald C. W., Wong, Tien-Yin, Mook-Kanamori, Dennis O., Tuomi, Tiinamaija, Chandak, Giriraj R., Collins, Francis S., Bharadwaj, Dwaipayan, Paré, Guillaume, Sale, Michèle M., Ahsan, Habibul, Motala, Ayesha A., Shu, Xiao-Ou, Park, Kyong-Soo, Jukema, J Wouter, Cruz, Miguel, Chen, Yii-Der Ida, Rich, Stephen S., McKean-Cowdin, Roberta, Grallert, Harald, Cheng, Ching-Yu, Ghanbari, Mohsen, Tai, E-Shyong, Dupuis, Josee, Kato, Norihiro, Laakso, Markku, Köttgen, Anna, Koh, Woon-Puay, Bowden, Donald W., Palmer, Colin N. A., Kooner, Jaspal S., Kooperberg, Charles, Liu, Simin, North, Kari E., Saleheen, Danish, Hansen, Torben, Pedersen, Oluf, Wareham, Nicholas J., Lee, Juyoung, Kim, Bong-Jo, Millwood, Iona Y., Walters, Robin G., Stefansson, Kari, Goodarzi, Mark O., Mohlke, Karen L., Langenberg, Claudia, Haiman, Christopher A., Loos, Ruth J. F., Florez, Jose C., Rader, Daniel J., Ritchie, Marylyn D., Zöllner, Sebastian, Mägi, Reedik, Denny, Joshua C., Yamauchi, Toshimasa, Kadowaki, Takashi, Chambers, John C., Ng, Maggie C. Y., Sim, Xueling, Below, Jennifer E., Tsao, Philip S., Chang, Kyong-Mi, McCarthy, Mark I., Meigs, James B., Mahajan, Anubha, Spracklen, Cassandra N., Mercader, Josep M., Boehnke, Michael, Rotter, Jerome I., Vujkovic, Marijana, Voight, Benjamin F., Morris, Andrew P., and Zeggini, Eleftheria
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Article - Abstract
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (P
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- 2023
9. Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing
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Jakubek, Yasminka A., primary, Zhou, Ying, additional, Stilp, Adrienne, additional, Bacon, Jason, additional, Wong, Justin, additional, Ozcan, Zuhal, additional, Arnett, Donna, additional, Barnes, Kathleen, additional, Bis, Josh, additional, Boerwinkle, Eric, additional, Carson, April, additional, Chasman, Daniel, additional, Cho, Michael, additional, Conomos, Matthew P., additional, Cox, Nancy, additional, Doyle, Margaret, additional, Fornage, Myriam, additional, Guo, Xiuqing, additional, Kardia, Sharon, additional, Lewis, Joshua P., additional, Loos, Ruth J., additional, Ma, Xiaolong, additional, Machiela, Mitchell, additional, Mack, Taralynn M., additional, Mathias, Rasika, additional, Mitchell, Braxton D., additional, North, Kari, additional, Pankratz, Nathan, additional, Peyser, Patricia, additional, Preuss, Michael H., additional, Psaty, Bruce, additional, Raffield, Laura M., additional, Vasan, Ramachandran S., additional, Redline, Susan, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Silverman, Edwin, additional, Smith, Jennifer, additional, Taub, Margaret, additional, Yun, Jeong, additional, Li, Yun, additional, Desai, Pinkal, additional, Bick, Alexander G., additional, Reiner, Alexander P., additional, Scheet, Paul, additional, and Auer, Paul L., additional
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- 2022
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10. Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-specific effects via GAUDI
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Sun, Quan, primary, Rowland, Bryce T., additional, Chen, Jiawen, additional, Mikhaylova, Anna V., additional, Avery, Christy, additional, Peters, Ulrike, additional, Lundin, Jessica, additional, Matise, Tara, additional, Buyske, Steve, additional, Tao, Ran, additional, Mathias, Rasika A., additional, Reiner, Alexander P., additional, Auer, Paul L., additional, Cox, Nancy J., additional, Kooperberg, Charles, additional, Thornton, Timothy A., additional, Raffield, Laura M., additional, and Li, Yun, additional
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- 2022
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11. The power of TOPMed imputation for the discovery of Latino enriched rare variants associated with type 2 diabetes
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Huerta-Chagoya, Alicia, primary, Schroeder, Philip, additional, Mandla, Ravi, additional, Deutsch, Aaron J., additional, Zhu, Wanying, additional, Petty, Lauren, additional, Yi, Xiaoyan, additional, Cole, Joanne B., additional, Udler, Miriam S., additional, Dornbos, Peter, additional, Porneala, Bianca, additional, DiCorpo, Daniel, additional, Liu, Ching-Ti, additional, Li, Josephine H., additional, Szczerbiński, Lukasz, additional, Kaur, Varinderpal, additional, Kim, Joohyun, additional, Lu, Yingchang, additional, Martin, Alicia, additional, Eizirik, Decio L., additional, Marchetti, Piero, additional, Marselli, Lorella, additional, Chen, Ling, additional, Srinivasan, Shylaja, additional, Todd, Jennifer, additional, Flannick, Jason, additional, Gubitosi-Klug, Rose, additional, Levitsky, Lynne, additional, Shah, Rachana, additional, Kelsey, Megan, additional, Burke, Brian, additional, Dabelea, Dana M., additional, Divers, Jasmin, additional, Marcovina, Santica, additional, Stalbow, Lauren, additional, Loos, Ruth J.F., additional, Darst, Burcu F., additional, Kooperberg, Charles, additional, Raffield, Laura M., additional, Haiman, Christopher, additional, Sun, Quan, additional, McCormick, Joseph B., additional, Fisher-Hoch, Susan P., additional, Ordoñez, Maria L., additional, Meigs, James, additional, Baier, Leslie J., additional, González-Villalpando, Clicerio, additional, González-Villalpando, Maria Elena, additional, Orozco, Lorena, additional, Moreno, Andrés, additional, Aguilar-Salinas, Carlos A., additional, Tusié, Teresa, additional, Dupuis, Josée, additional, Ng, Maggie C.Y., additional, Manning, Alisa, additional, Highland, Heather M., additional, Cnop, Miriam, additional, Hanson, Robert, additional, Below, Jennifer, additional, Florez, Jose C., additional, Leong, Aaron, additional, and Mercader, Josep M., additional
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- 2022
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12. Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: The Framingham Heart Study
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Keshawarz, Amena, primary, Bui, Helena, additional, Joehanes, Roby, additional, Ma, Jiantao, additional, Liu, Chunyu, additional, Huan, Tianxiao, additional, Hwang, Shih-Jen, additional, Tejada, Brandon, additional, Sooda, Meera, additional, Courchesne, Paul, additional, Munson, Peter J., additional, Demirkale, Cumhur Y., additional, Yao, Chen, additional, Heard-Costa, Nancy L, additional, Pitsillides, Achilleas N, additional, Lin, Honghuang, additional, Liu, Ching-Ti, additional, Wang, Yuxuan, additional, Peloso, Gina M, additional, Lundin, Jessica, additional, Haessler, Jeffrey, additional, Du, Zhaohui, additional, Cho, Michael, additional, Hersh, Craig P, additional, Castaldi, Peter, additional, Raffield, Laura M., additional, Wen, Jia, additional, Li, Yun, additional, Reiner, Alexander P., additional, Feolo, Mike, additional, Sharopova, Nataliya, additional, Vasan, Ramachandran, additional, Silverman, Edwin K, additional, DeMeo, Dawn L, additional, Carson, April P, additional, Kooperberg, Charles, additional, and Levy, Daniel, additional
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- 2022
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13. Genetic Examination of Hematological Parameters in SARS-CoV-2 Infection and COVID-19
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Rowland, Bryce, primary, Sun, Quan, additional, Wang, Wanjiang, additional, Miller-Fleming, Tyne, additional, Cox, Nancy, additional, Graff, Mariaelisa, additional, Faucon, Annika, additional, Shuey, Megan, additional, Blue, Elizabeth E., additional, Auer, Paul, additional, Li, Yun, additional, Sankaran, Vijay G., additional, Reiner, Alexander P., additional, and Raffield, Laura M., additional
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- 2022
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14. Clonal hematopoiesis is driven by aberrant activation of TCL1A
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Weinstock, Joshua S., primary, Gopakumar, Jayakrishnan, additional, Burugula, Bala Bharathi, additional, Uddin, Md Mesbah, additional, Jahn, Nikolaus, additional, Belk, Julia A., additional, Daniel, Bence, additional, Ly, Nghi, additional, Mack, Taralyn M., additional, Laurie, Cecelia A., additional, Broome, Jai G., additional, Taylor, Kent D., additional, Guo, Xiuqing, additional, Sinner, Moritz F., additional, von Falkenhausen, Aenne S., additional, Kääb, Stefan, additional, Shuldiner, Alan R., additional, O’Connell, Jeffrey R., additional, Lewis, Joshua P., additional, Boerwinkle, Eric, additional, Barnes, Kathleen C., additional, Chami, Nathalie, additional, Kenny, Eimear E., additional, Loos, Ruth J., additional, Fornage, Myriam, additional, Hou, Lifang, additional, Lloyd-Jones, Donald M., additional, Redline, Susan, additional, Cade, Brian E., additional, Psaty, Bruce M., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Silverman, Edwin K., additional, Yun, Jeong H., additional, Qiao, Dandi, additional, Palmer, Nicholette D., additional, Freedman, Barry I., additional, Bowden, Donald W., additional, Cho, Michael H., additional, DeMeo, Dawn L., additional, Vasan, Ramachandran S., additional, Yanek, Lisa R., additional, Becker, Lewis C., additional, Kardia, Sharon, additional, Peyser, Patricia A., additional, He, Jiang, additional, Rienstra, Michiel, additional, Harst, Pim Van der, additional, Kaplan, Robert, additional, Heckbert, Susan R., additional, Smith, Nicholas L., additional, Wiggins, Kerri L., additional, Arnett, Donna K., additional, Irvin, Marguerite R., additional, Tiwari, Hemant, additional, Cutler, Michael J., additional, Knight, Stacey, additional, Muhlestein, J Brent., additional, Correa, Adolfo, additional, Raffield, Laura M., additional, Gao, Yan, additional, Andrade, Mariza de, additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Tracy, Russell P., additional, Konkle, Barbara A., additional, Johnsen, Jill M., additional, Wheeler, Marsha M., additional, Smith, J. Gustav, additional, Melander, Olle, additional, Nilsson, Peter M., additional, Custer, Brian S., additional, Duggirala, Ravindranath, additional, Curran, Joanne E., additional, Blangero, John, additional, McGarvey, Stephen, additional, Williams, L. Keoki, additional, Xiao, Shujie, additional, Yang, Mao, additional, Gu, C. Charles., additional, Chen, Yii-Der Ida., additional, Lee, Wen-Jane, additional, Marcus, Gregory M., additional, Kane, John P., additional, Pullinger, Clive R., additional, Shoemaker, M. Benjamin, additional, Darbar, Dawood, additional, Roden, Dan, additional, Albert, Christine, additional, Kooperberg, Charles, additional, Zhou, Ying, additional, Manson, JoAnn E., additional, Desai, Pinkal, additional, Johnson, Andrew, additional, Mathias, Rasika, additional, Blackwell, Thomas W., additional, Abecasis, Goncalo R., additional, Smith, Albert V., additional, Kang, Hyun M., additional, Satpathy, Ansuman T., additional, Natarajan, Pradeep, additional, Kitzman, Jacob, additional, Whitsel, Eric, additional, Reiner, Alexander P., additional, Bick, Alexander G., additional, and Jaiswal, Sidd, additional
- Published
- 2021
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15. Assay-related Differences in SuPAR Levels: Implications for Measurement and Data Interpretation
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Hayek, Salim S., primary, Raffield, Laura M., additional, Gao, Yan, additional, Engstrom, Gunnar, additional, Quyyumi, Arshed A., additional, Reiner, Alexander P., additional, and Reiser, Jochen, additional
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- 2021
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16. Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types
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Lagler, Taylor M., primary, Yang, Yuchen, additional, Harigaya, Yuriko, additional, Sankaran, Vijay G., additional, Hu, Ming, additional, Reiner, Alexander P., additional, Raffield, Laura M., additional, Wen, Jia, additional, and Li, Yun, additional
- Published
- 2021
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17. A large-scale transcriptome-wide association study (TWAS) of ten blood cell phenotypes reveals complexities of TWAS fine-mapping
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Tapia, Amanda L, primary, Rowland, Bryce T, additional, Rosen, Jonathan D, additional, Preuss, Michael, additional, Young, Kris, additional, Graff, Misa, additional, Choquet, Hélène, additional, Couper, David J, additional, Buyske, Steve, additional, Bien, Stephanie A, additional, Jorgenson, Eric, additional, Kooperberg, Charles, additional, Loos, Ruth J.F., additional, Morrison, Alanna C, additional, North, Kari E, additional, Yu, Bing, additional, Reiner, Alexander P, additional, Li, Yun, additional, and Raffield, Laura M, additional
- Published
- 2021
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18. From GWAS Variant to Function: a Study of ~148,000 Variants for Blood Cell Traits
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Sun, Quan, primary, Crowley, Cheynna A., additional, Huang, Le, additional, Wen, Jia, additional, Chen, Jiawen, additional, Bao, Erik L., additional, Auer, Paul L., additional, Lettre, Guillaume, additional, Reiner, Alexander P., additional, Sankaran, Vijay G., additional, Raffield, Laura M., additional, and Li, Yun, additional
- Published
- 2021
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19. Genetic Underpinnings of Regional Adiposity Distribution in African Americans: Assessments from the Jackson Heart Study
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Anwar, Mohammad Y., primary, Raffield, Laura M., additional, Lange, Leslie A., additional, Correa, Adolfo, additional, and Taylor, Kira C., additional
- Published
- 2020
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- View/download PDF
20. Analyses of Biomarker Traits in Diverse UK Biobank Participants Identify Associations Missed by European-centric Analysis Strategies
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Sun, Quan, primary, Graff, Misa, additional, Rowland, Bryce, additional, Wen, Jia, additional, Huang, Le, additional, Lee, Moa P., additional, Avery, Christy L., additional, Franceschini, Nora, additional, North, Kari E., additional, Li, Yun, additional, and Raffield, Laura M., additional
- Published
- 2020
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21. A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program
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Stilp, Adrienne M., primary, Emery, Leslie S., additional, Broome, Jai G., additional, Buth, Erin J., additional, Khan, Alyna T., additional, Laurie, Cecelia A., additional, Wang, Fei Fei, additional, Wong, Quenna, additional, Chen, Dongquan, additional, D’Augustine, Catherine M., additional, Heard-Costa, Nancy L., additional, Hohensee, Chancellor R., additional, Johnson, William Craig, additional, Juarez, Lucia D., additional, Liu, Jingmin, additional, Mutalik, Karen M., additional, Raffield, Laura M., additional, Wiggins, Kerri L., additional, de Vries, Paul S., additional, Kelly, Tanika N., additional, Kooperberg, Charles, additional, Natarajan, Pradeep, additional, Peloso, Gina M., additional, Peyser, Patricia A., additional, Reiner, Alex P., additional, Arnett, Donna K., additional, Aslibekyan, Stella, additional, Barnes, Kathleen C., additional, Bielak, Lawrence F., additional, Bis, Joshua C., additional, Cade, Brian E., additional, Chen, Ming-Huei, additional, Correa, Adolfo, additional, Cupples, L. Adrienne, additional, de Andrade, Mariza, additional, Ellinor, Patrick T., additional, Fornage, Myriam, additional, Franceschini, Nora, additional, Gan, Weiniu, additional, Ganesh, Santhi K., additional, Graffelman, Jan, additional, Grove, Megan L., additional, Guo, Xiuqing, additional, Hawley, Nicola L., additional, Hsu, Wan-Ling, additional, Jackson, Rebecca D., additional, Jaquish, Cashell E., additional, Johnson, Andrew D., additional, Kardia, Sharon LR, additional, Kelly, Shannon, additional, Lee, Jiwon, additional, Mathias, Rasika A., additional, McGarvey, Stephen T., additional, Mitchell, Braxton D., additional, Montasser, May E., additional, Morrison, Alanna C., additional, North, Kari E., additional, Nouraie, Seyed Mehdi, additional, Oelsner, Elizabeth C., additional, Pankratz, Nathan, additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Smith, Jennifer A., additional, Taylor, Kent D., additional, Vasan, Ramachandran S., additional, Weeks, Daniel E., additional, Weiss, Scott T., additional, Wilson, Carla G., additional, Yanek, Lisa R., additional, Psaty, Bruce M., additional, Heckbert, Susan R., additional, and Laurie, Cathy C., additional
- Published
- 2020
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22. Association of mitochondrial DNA copy number with cardiometabolic diseases in a large cross-sectional study of multiple ancestries
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Liu, Xue, primary, Longchamps, Ryan J., additional, Wiggins, Kerri, additional, Raffield, Laura M., additional, Bielak, Lawrence F., additional, Zhao, Wei, additional, Pitsillides, Achilleas, additional, Blackwell, Thomas, additional, Yao, Jie, additional, Guo, Xiuqing, additional, Kurniansyah, Nuzulul, additional, Thyagarajan, Bharat, additional, Pankratz, Nathan, additional, Rich, Stephen S., additional, Taylor, Kent D., additional, Peyser, Patricia A., additional, Heckbert, Susan R., additional, Seshadri, Sudha, additional, Cupples, L Adrienne, additional, Boerwinkle, Eric, additional, Grove, Megan L., additional, Larson, Nicholas, additional, Smith, Jennifer A., additional, Vasan, Ramachandran S, additional, Sofer, Tamar, additional, Fitzpatrick, Annette L, additional, Fornage, Myriam, additional, Ding, Jun, additional, Correa, Adolfo, additional, Abecasis, Goncalo, additional, Psaty, Bruce M., additional, Wilson, James G., additional, Levy, Daniel, additional, Rotter, Jerome I., additional, Bis, Joshua C., additional, Satizabal, Claudia L, additional, Arking, Dan E., additional, and Liu, Chunyu, additional
- Published
- 2020
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23. Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
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Chen, Ming-Huei, primary, Raffield, Laura M., additional, Mousas, Abdou, additional, Sakaue, Saori, additional, Huffman, Jennifer E., additional, Jiang, Tao, additional, Akbari, Parsa, additional, Vuckovic, Dragana, additional, Bao, Erik L., additional, Moscati, Arden, additional, Zhong, Xue, additional, Manansala, Regina, additional, Laplante, Véronique, additional, Chen, Minhui, additional, Lo, Ken Sin, additional, Qian, Huijun, additional, Lareau, Caleb A., additional, Beaudoin, Mélissa, additional, Akiyama, Masato, additional, Bartz, Traci M., additional, Ben-Shlomo, Yoav, additional, Beswick, Andrew, additional, Bork-Jensen, Jette, additional, Bottinger, Erwin P., additional, Brody, Jennifer A., additional, van Rooij, Frank J.A., additional, Chitrala, Kumaraswamynaidu, additional, Cho, Kelly, additional, Choquet, Hélène, additional, Correa, Adolfo, additional, Danesh, John, additional, Di Angelantonio, Emanuele, additional, Dimou, Niki, additional, Ding, Jingzhong, additional, Elliott, Paul, additional, Esko, Tõnu, additional, Evans, Michele K., additional, Floyd, James S., additional, Broer, Linda, additional, Grarup, Niels, additional, Guo, Michael H., additional, Greinacher, Andreas, additional, Haessler, Jeff, additional, Hansen, Torben, additional, Howson, Joanna M. M., additional, Huang, Wei, additional, Jorgenson, Eric, additional, Kacprowski, Tim, additional, Kähönen, Mika, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Karthikeyan, Savita, additional, Koskeridis, Fotis, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Lerch, Markus M., additional, Linneberg, Allan, additional, Liu, Yongmei, additional, Lyytikäinen, Leo-Pekka, additional, Manichaikul, Ani, additional, Matsuda, Koichi, additional, Mohlke, Karen L., additional, Mononen, Nina, additional, Murakami, Yoshinori, additional, Nadkarni, Girish N., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ouwehand, Willem H., additional, Pankratz, Nathan, additional, Pedersen, Oluf, additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Roberts, David J., additional, Rich, Stephen S., additional, Rodriguez, Benjamin A.T., additional, Rosen, Jonathan D., additional, Rotter, Jerome I., additional, Schubert, Petra, additional, Spracklen, Cassandra N., additional, Surendran, Praveen, additional, Tang, Hua, additional, Tardif, Jean-Claude, additional, Ghanbari, Mohsen, additional, Völker, Uwe, additional, Völzke, Henry, additional, Watkins, Nicholas A., additional, Zonderman, Alan B., additional, Million Veteran Program, VA, additional, Wilson, Peter W.F., additional, Li, Yun, additional, Butterworth, Adam S., additional, Gauchat, Jean-François, additional, Chiang, Charleston W.K., additional, Li, Bingshan, additional, Loos, Ruth J.F., additional, Astle, William J., additional, Evangelou, Evangelos, additional, Sankaran, Vijay G., additional, Okada, Yukinori, additional, Soranzo, Nicole, additional, Johnson, Andrew D., additional, Reiner, Alexander P., additional, Auer, Paul L., additional, and Lettre, Guillaume, additional
- Published
- 2020
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24. Common genetic risk variants identified in the SPARK cohort implicate DDHD2 as a novel autism risk gene
- Author
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Matoba, Nana, primary, Liang, Dan, additional, Sun, Huaigu, additional, Aygün, Nil, additional, McAfee, Jessica C., additional, Davis, Jessica E., additional, Raffield, Laura M., additional, Qian, Huijun, additional, Piven, Joseph, additional, Li, Yun, additional, Kosuri, Sriam, additional, Won, Hyejung, additional, and Stein, Jason L., additional
- Published
- 2020
- Full Text
- View/download PDF
25. Novel genetic determinants of telomere length from a multi-ethnic analysis of 75,000 whole genome sequences in TOPMed
- Author
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Taub, Margaret A, Weinstock, Joshua S, Iyer, Kruthika R, Yanek, Lisa R, Conomos, Matthew P, Brody, Jennifer A, Keramati, Ali, Laurie, Cecelia A, Arvanitis, Marios, Smith, Albert V, Lane, John, Becker, Lewis C, Bis, Joshua C, Blangero, John, Bleecker, Eugene R, Burchard, Esteban G, Celedon, Juan C, Chang, Yen Pei C, Custer, Brian, Darbar, Dawood, de las Fuentes, Lisa, DeMeo, Dawn L, Freedman, Barry I, Garrett, Melanie E, Gladwin, Mark T, Heckbert, Susan R, Hidalgo, Bertha A, Ingram, Christie, Irvin, Marguerite R, Craig Johnson, W, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E, Peyser, Patricia A, Rafaels, Nicholas, Raffield, Laura M, Weeks, Daniel E, Wheeler, Marsha M, Keoki Williams, L., Zhao, Wei, Armanios, Mary, Aslibekyan, Stella, Auer, Paul L, Bowden, Donald W, Cade, Brian E, Yii-Der Chen, Ida, Cho, Michael H, Cupples, L Adrienne, Curran, Joanne E, Daya, Michelle, Deka, Ranjan, Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M, Kenny, Eimear E, Levin, Albert M, Liu, Chunyu, Minster, Ryan L, Nouraie, Mehdi, Sabino, Ester C, Smith, Jennifer A, Smith, Nicholas L, Lasky Su, Jessica, Telen, Marilyn J, Tiwari, Hemant K, Tracy, Russell P, White, Marquitta J, Zhang, Yingze, Wiggins, Kerri L, Weiss, Scott T, Vasan, Ramachandran S, Taylor, Kent D, Sinner, Moritz F, Silverman, Edwin K, Benjamin Shoemaker, M., Sheu, Wayne H-H, Rotter, Jerome I, Redline, Susan, Psaty, Bruce M, Peralta, Juan M, Palmer, Nicholette D, Loos, Ruth JF, Montgomery, Courtney G, Mitchell, Braxton D, Meyers, Deborah A, McGarvey, Stephen T, Mak, Angel CY, Kumar, Rajesh, Kooperberg, Charles, Konkle, Barbara A, Kelly, Shannon, Kardia, Sharon LR, Kaplan, Robert, He, Jiang, Gui, Hongsheng, Fornage, Myriam, Ellinor, Patrick T, de Andrade, Mariza, Correa, Adolfo, Boerwinkle, Eric, Barnes, Kathleen C, Ashley-Koch, Allison E, Arnett, Donna K, Albert, Christine, Laurie, Cathy C, Abecasis, Goncalo, Aviv, Abraham, Nickerson, Deborah A, Wilson, James G, Rich, Stephen S, Levy, Daniel, Battle, Alexis, Blackwell, Thomas W, Ruczinski, Ingo, Thornton, Timothy, O’Connell, Jeff, Perry, James A, Pankratz, Nathan, Reiner, Alexander P, and Mathias, Rasika A
- Abstract
Telomeres shorten in replicating somatic cells and with age; in human leukocytes, telomere length (TL) is associated with a host of aging-related diseases 1,2 . To date, 16 genome-wide association studies (GWAS) have identified twenty-three loci associated with leukocyte TL 3–18 , but prior studies were primarily in individuals of European and Asian ancestry and relied on laboratory assays including Southern Blot and qPCR to quantify TL. Here, we estimated TL bioinformatically, leveraging whole genome sequencing (WGS) of whole blood from n=75,176 subjects in the Trans-Omics for Precision Medicine (TOPMed) Program. We performed the largest multi-ethnic and only WGS-based genome-wide association analysis of TL to date. We identified 22 associated loci (p-value
- Published
- 2019
- Full Text
- View/download PDF
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