1. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: Randomized Control Trial in Singapore
- Author
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Dorothy Hui Lin Ng, Kheng Sit Lim, Deborah Lai, Kwan Ki Karrie Ko, Bee Tin Goh, Preethi Balan, Moi Lin Ling, Chaminda Jayampath Seneviratne, Nadeeka S. Udawatte, Indumathi Venkatachalam, Lynette Oon, and Xiang Ying Jean Sim
- Subjects
0301 basic medicine ,Male ,Saliva ,Mouthwashes ,Cetylpyridinium chloride ,law.invention ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Mouth rinse ,Chlorhexidine gluconate ,030212 general & internal medicine ,Povidone-Iodine ,Singapore ,Chlorhexidine ,Dental procedures ,General Medicine ,Middle Aged ,Viral Load ,Mouth-rinses ,Clinical trial ,Treatment Outcome ,Infectious Diseases ,Female ,Viral load ,medicine.drug ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,Antiseptics ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,030106 microbiology ,Cetylpyridinium ,03 medical and health sciences ,Young Adult ,Internal medicine ,medicine ,Humans ,Original Paper ,SARS-CoV-2 ,business.industry ,COVID-19 ,Fold change ,COVID-19 Drug Treatment ,chemistry ,Anti-Infective Agents, Local ,business - Abstract
The presence of high SARS-coronavirus 2 (SARS-CoV-2) titres in saliva may result in transmission of the virus and increase the risk of COVID-19 infection. This is particularly important as significant amounts of aerosols are generated during dental procedures, posing risk to dental care personnel and patients. Thus, reducing the titres of SARS-CoV-2 in the saliva of infected patients could be one of the key approaches to reduce the risk of COVID-19 transmission during dental procedures. In this randomised control trial, the efficacy of three commercial mouth-rinse viz. povidone-iodine (PI), chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC), in reducing the salivary SARS-CoV-2 viral load in COVID-19 positive patients were compared with water. A total of 36 COVID-19 positive patients were recruited, of which 16 patients were randomly assigned to four groups— PI group (n=4), CHX group (n=6), CPC group (n=4) and water as control group (n=2). Saliva samples were collected from all patients at baseline and at 5 min, 3 h and 6 h post-application of mouth-rinses/water. The samples were subjected to SARS-CoV-2 RT-PCR analysis. The fold change of Ct values were significantly increased in CPC group at 5 minutes and 6 h time points (p
- Published
- 2020