1. SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants
- Author
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Philip Cunningham, Stuart Turville, Fabienne Brilot, David Brown, Rebeca Rockett, Vitali Sintchenko, Markus Hoffman, Gregory J. Dore, William D. Rawlinson, Sonia R Isaacs, D.R. Darley, Vennila Mathivanan, Daniele Vitale, Vera Merheb, Dominic E. Dwyer, Fiona X Z Lee, Deepti Pilli, Gregory J. Walker, Fiona Tea, Alberto Ospina Stella, Anupriya Aggarwal, Veronica C. Hoad, Iain B Gosbell, David O. Irving, Gail V. Matthews, Anthony D. Kelleher, and Stefan Pöhlmann
- Subjects
0303 health sciences ,biology ,Coronavirus disease 2019 (COVID-19) ,viruses ,media_common.quotation_subject ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Longevity ,Virology ,Neutralization ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Antigen ,biology.protein ,Potency ,Antibody ,Neutralizing antibody ,030217 neurology & neurosurgery ,030304 developmental biology ,media_common - Abstract
The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 RT-PCR-confirmed COVID-19 individuals with detailed demographics and followed up to seven months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization were associated with COVID-19 severity. A subgroup of ‘high responders’ maintained high neutralizing responses over time, representing ideal convalescent plasma therapy donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal plasma donors and vaccine monitoring and design.One Sentence SummaryNeutralizing antibody responses to SARS-CoV-2 are sustained, associated with COVID19 severity, and evaded by emerging viral variants
- Published
- 2020