48 results on '"Holmes, Michael, V"'
Search Results
2. PCSK9genetic variants and risk of vascular and non-vascular diseases in Chinese and UK populations
3. Systematic disease-agnostic identification of therapeutically actionable targets using the genetics of human plasma proteins
4. Polygenic score for sleep duration in relation to risk of Alzheimer’s disease: results from the UK Biobank
5. Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations
6. Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization
7. Associations of adiposity, kidney stone disease, and serum calcium concentrations; observational and genetic epidemiological studies
8. The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: A Mendelian randomization study
9. Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization study
10. Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomization study
11. The relationship between BMI and COVID-19: exploring misclassification and selection bias in a two-sample Mendelian randomisation study
12. An atlas of associations between polygenic risk scores from across the human phenome and circulating metabolic biomarkers
13. Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomization
14. Dominant role of abdominal adiposity in circulating lipoprotein, lipid, and metabolite levels in UK Biobank: Mendelian randomization study
15. The role of obesity in female reproductive conditions: A Mendelian Randomisation study
16. The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: mendelian randomization study
17. Assessing the efficacy and safety of angiotensinogen inhibition using human genetics
18. A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance
19. Using Mendelian Randomization to Improve the Design of Randomized Trials
20. Effects of apolipoprotein B on the lifespan and risks of major disease including type 2 diabetes: a Mendelian randomization analysis using outcomes in first-degree relatives
21. A phenome-wide multi-directional Mendelian randomization analysis of atrial fibrillation
22. Body mass index and heart failure risk: a cohort study in 1.5 million individuals and Mendelian randomisation analysis
23. Obesity as a cause of kidney disease – insights from Mendelian randomisation studies
24. Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to SARS-CoV-2 severity
25. Assessing the efficacy and safety of angiotensinogen inhibition using human genetics
26. Metabolic Biomarkers for Peripheral Artery Disease Compared with Coronary Artery Disease: Lipoprotein and metabolite profiling of 31,657 individuals from five prospective cohorts
27. Genetic inhibition of interleukin-6 receptor signaling and Covid-19
28. Body muscle gain and markers of cardiovascular disease susceptibility in young adulthood: prospective cohort study
29. Genomic evaluation of circulating proteins for drug target characterisation and precision medicine
30. Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200,000 men in UK Biobank
31. Colocalization highlights genes in hypothalamic–pituitary–gonadal axis as potentially mediating polycystic ovary syndrome risk
32. Apolipoprotein B underlies the causal relationship of circulating blood lipids with coronary heart disease
33. Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
34. Genetic variation in apolipoprotein A-I concentrations and risk of coronary artery disease
35. Lifelong genetically lowered sclerostin and risk of cardiovascular disease
36. Causal relevance of obesity on the leading causes of death in women and men: A Mendelian randomization study
37. What explains the effect of education on cardiovascular disease? Applying Mendelian randomization to identify the consequences of education inequality
38. Direct estimation of HDL-mediated cholesterol efflux capacity from serum
39. CETP inhibition and ADCY9 genotype: evidence of a qualitative pharmacogenetic interaction in cardiovascular disease?
40. PCSK9 genetic variants, life-long lowering of LDL-cholesterol and cognition: a large-scale Mendelian randomization study
41. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
42. Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition
43. Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics
44. GWAS identifies novel risk locus for erectile dysfunction and implicates hypothalamic neurobiology and diabetes in etiology
45. Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment
46. GWAS identifies 10 loci for objectively-measured physical activity and sleep with causal roles in cardiometabolic disease.
47. Education and coronary heart disease: a Mendelian randomization study
48. Cannabis use and risk of schizophrenia: a Mendelian randomization study
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