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Start Over Author "Chen Jichao" Publisher cold spring harbor laboratory
19 results on '"Chen Jichao"'

4. An inducible tricolor reporter mouse for simultaneous imaging of lysosomes, mitochondria and microtubules

Author

Hutchison, Vera, Lynch, Anne, Gutierrez Gamez, Andrés Mauricio, and Chen, Jichao

Subjects
Article
Abstract

Cell-type-specific use of the same DNA blueprint generates diverse cell types. Such diversity must also be executed via differential deployment of the same subcellular machinery. However, our understanding of the size, distribution, and dynamics of subcellular machinery in native tissues, and their connection to cellular diversity, remain limited. We generate and characterize an inducible tricolor reporter mouse, dubbed “kaleidoscope”, for simultaneous imaging of lysosomes, mitochondria and microtubules in any cell type and at a single cell resolution. The expected subcellular compartments are labeled in culture and in tissues with no impact on cellular and organismal viability. Quantitative and live imaging of the tricolor reporter captures cell-type-specific organelle features and kinetics in the lung, as well as their changes after Sendai virus infection.Yap/Tazmutant lung epithelial cells undergo accelerated lamellar body maturation, a subcellular manifestation of their molecular defects. A comprehensive toolbox of reporters for all subcellular structures is expected to transform our understanding of cell biology in tissues.SUMMARY STATEMENTOur understanding of subcellular machinery is often inferred from that in cultured cells. Hutchison et al. have generated a tricolor tunable reporter mouse for simultaneous imaging of lysosomes, mitochondria and microtubules in the native tissues at a single-cell resolution.

Published
2023

5. Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial metabolic reprogramming

Author

Wang, Yongxing, primary, Kulkarni, Vikram V., additional, García, Jezreel Pantaleón, additional, Leiva-Juárez, Miguel M., additional, Goldblatt, David L., additional, Gulraiz, Fahad, additional, Chen, Jichao, additional, Donepudi, Sri Ramya, additional, Lorenzi, Philip L., additional, Wang, Hao, additional, Wong, Lee-Jun, additional, Tuvim, Michael J., additional, and Evans, Scott E., additional

Published
2023
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6. PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

Author

Kim, Bongjun, primary, Huang, Yuanjian, additional, Ko, Kyung-Pil, additional, Zhang, Shengzhe, additional, Zou, Gengyi, additional, Zhang, Jie, additional, Kim, Moonjong, additional, Little, Danielle, additional, Ellis, Lisandra Vila, additional, Paschini, Margherita, additional, Jun, Sohee, additional, Park, Kwon-Sik, additional, Chen, Jichao, additional, Kim, Carla, additional, and Park, Jae-Il, additional

Published
2022
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8. An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Author

Han, Guangchun, primary, Sinjab, Ansam, additional, Treekitkarnmongkol, Warapen, additional, Lu, Wei, additional, Serrano, Alejandra G., additional, Hernandez, Sharia D., additional, Rahal, Zahraa, additional, Cao, Xuanye, additional, Dai, Enyu, additional, Gomez-Bolanos, Lorena I., additional, Parra, Edwin R., additional, Negrao, Marcelo Vailati, additional, Cascone, Tina, additional, Sepesi, Boris, additional, Moghaddam, Seyed Javad, additional, Chen, Jichao, additional, Dubinett, Steven M., additional, Scheet, Paul, additional, Fujimoto, Junya, additional, Solis, Luisa M., additional, Wistuba, Ignacio I., additional, Stevenson, Christopher S., additional, Spira, Avrum E., additional, Wang, Linghua, additional, and Kadara, Humam, additional

Published
2022
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13. Resolving the spatial and cellular architecture of lung adenocarcinoma by multi-region single-cell sequencing

Author

Sinjab, Ansam, primary, Han, Guangchun, additional, Treekitkarnmongkol, Warapen, additional, Hara, Kieko, additional, Brennan, Patrick, additional, Dang, Minghao, additional, Hao, Dapeng, additional, Wang, Ruiping, additional, Dai, Enyu, additional, Dejima, Hitoshi, additional, Zhang, Jiexin, additional, Bogatenkova, Elena, additional, Sanchez-Espiridion, Beatriz, additional, Chang, Kyle, additional, Little, Danielle R., additional, Bazzi, Samer, additional, Tran, Linh, additional, Krysan, Kostyantyn, additional, Behrens, Carmen, additional, Duose, Dzifa, additional, Parra, Edwin R., additional, Raso, Maria Gabriela, additional, Solis, Luisa M., additional, Fukuoka, Junya, additional, Zhang, Jianjun, additional, Sepesi, Boris, additional, Cascone, Tina, additional, Byers, Lauren, additional, Gibbons, Don L., additional, Chen, Jichao, additional, Moghaddam, Seyed Javad, additional, Ostrin, Edwin J., additional, Rosen, Daniel G., additional, Heymach, John V., additional, Scheet, Paul, additional, Dubinett, Steven, additional, Fujimoto, Junya, additional, Wistuba, Ignacio I., additional, Stevenson, Christopher S., additional, Spira, Avrum E., additional, Wang, Linghua, additional, and Kadara, Humam, additional

Published
2020
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14. Single-cell analysis of human lung epithelia reveals concomitant expression of the SARS-CoV-2 receptor ACE2 with multiple virus receptors and scavengers in alveolar type II cells

Author

Han, Guangchun, primary, Sinjab, Ansam, additional, Treekitkarnmongkol, Warapen, additional, Brennan, Patrick, additional, Hara, Kieko, additional, Chang, Kyle, additional, Bogatenkova, Elena, additional, Sanchez-Espiridion, Beatriz, additional, Behrens, Carmen, additional, Gao, Boning, additional, Girard, Luc, additional, Zhang, Jianjun, additional, Sepesi, Boris, additional, Cascone, Tina, additional, Byers, Lauren, additional, Gibbons, Don L., additional, Chen, Jichao, additional, Moghaddam, Seyed Javad, additional, Ostrin, Edwin J., additional, Fujimoto, Junya, additional, Shay, Jerry, additional, Heymach, John V., additional, Minna, John D., additional, Dubinett, Steven, additional, Scheet, Paul A., additional, Wistuba, Ignacio I., additional, Hill, Edward, additional, Telesco, Shannon, additional, Stevenson, Christopher, additional, Spira, Avrum E., additional, Wang, Linghua, additional, and Kadara, Humam, additional

Published
2020
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18. Aerosolized TLR Agonists Suppress Acute Sendai Virus Lung Infection and Chronic Airway Disease in Mice

Author

Goldblatt, David L., primary, Flores, Jose R., additional, Valverde Ha, Gabriella, additional, Jaramillo, Ana M., additional, Tkachman, Sofya, additional, Kirkpatrick, Carson T., additional, Wali, Shradha, additional, Hernandez, Belinda, additional, Ost, David E., additional, Scott, Brenton L., additional, Chen, Jichao, additional, Evans, Scott E., additional, Tuvim, Michael J., additional, and Dickey, Burton F., additional

Published
2019
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19. Super-enhancer impairment is a link between MLL4-inactivated lung tumors and their vulnerability to glycolysis pathway inhibition

Author

Alam, Hunain, primary, Tang, Ming, additional, Maitituoheti, Mayinuer, additional, Dhar, Shilpa S., additional, Amin, Samir, additional, Gu, Bingnan, additional, Chen, Tsai-Yu, additional, Lin, Yu-His, additional, Chen, Jichao, additional, Muller, Florian, additional, DeMayo, Francesco J., additional, Baseler, Laura, additional, Rai, Kunal, additional, and Lee, Min Gyu, additional

Published
2018
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