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Your search keyword '"Ansari, M. Azim"' showing total 19 results
Start Over Author "Ansari, M. Azim" Publisher cold spring harbor laboratory
19 results on '"Ansari, M. Azim"'

1. Pan-genotypic probe-based enrichment to improve efficiency of Hepatitis B virus sequencing

Author

Lumley, Sheila F, primary, Jennings, Daisy, additional, Waddilove, Elizabeth, additional, Trebes, Amy, additional, Delphin, Marion, additional, Downs, Louise O, additional, MacIntyre-Cockett, George, additional, Wu, Yanxia, additional, Chaudron, Sandra, additional, de Lara, Catherine, additional, Chai, Haiting, additional, Maponga, Tongai G, additional, Martin, Jacqueline, additional, Collier, Jane, additional, Ip, Camilla LC, additional, Barnes, Eleanor, additional, Bonsall, David, additional, Piazza, Paolo, additional, Ansari, M. Azim, additional, and Matthews, Philippa C, additional

Published
2023
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2. Association between disease severity and co-detection of respiratory pathogens in infants with RSV infection

Author

Lin, Gu-Lung, primary, Drysdale, Simon B, additional, Snape, Matthew D, additional, O’Connor, Daniel, additional, Brown, Anthony, additional, MacIntyre-Cockett, George, additional, Mellado-Gomez, Esther, additional, de Cesare, Mariateresa, additional, Ansari, M Azim, additional, Bonsall, David, additional, Bray, James E, additional, Jolley, Keith A, additional, Bowden, Rory, additional, Aerssens, Jeroen, additional, Bont, Louis, additional, Openshaw, Peter J M, additional, Martinon-Torres, Federico, additional, Nair, Harish, additional, Golubchik, Tanya, additional, and Pollard, Andrew J, additional

Published
2023
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3. Efficacy of ultra-short, response-guided sofosbuvir and daclatasvir therapy for Hepatitis C: a single arm mechanistic pilot study

Author

Flower, Barnaby, primary, Hung, Le Manh, additional, McCabe, Leanne, additional, Ansari, M. Azim, additional, Le Ngoc, Chau, additional, Vo Thi, Thu, additional, Vu Thi Kim, Hang, additional, Nguyen Thi Ngoc, Phuong, additional, Phuong, Le Thanh, additional, Quang, Vo Minh, additional, Trong, Thuan Dang, additional, Le Thi, Thao, additional, Bao, Tran Nguyen, additional, Kingsley, Cherry, additional, Smith, David, additional, Hoglund, Richard M., additional, Tarning, Joel, additional, Kestelyn, Evelyne, additional, Pett, Sarah L, additional, van Doorn, Rogier, additional, van Nuil, Jennifer Ilo, additional, Turner, Hugo, additional, Thwaites, Guy, additional, Barnes, Eleanor, additional, Rahman, Motiur, additional, Walker, Ann Sarah, additional, Day, Jeremy, additional, Van Vinh Chau, Nguyen, additional, and Cooke, Graham S, additional

Published
2022
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5. Durability of ChAdOx1 nCov-19 (AZD1222) vaccination in people living with HIV - responses to SARS-CoV-2, variants of concern and circulating coronaviruses

Author

Ogbe, Ane, primary, Pace, Mathew, additional, Bittaye, Mustapha, additional, Tipoe, Timothy, additional, Adele, Sandra, additional, Alagaratnam, Jasmini, additional, Aley, Parvinder K, additional, Ansari, M. Azim, additional, Bara, Anna, additional, Broadhead, Samantha, additional, Brown, Anthony, additional, Brown, Helen, additional, Cappuccini, Federica, additional, Cinardo, Paola, additional, Dejnirattisai, Wanwisa, additional, Ewer, Katie J., additional, Fok, Henry, additional, Folegatti, Pedro M., additional, Fowler, Jamie, additional, Godfrey, Leila, additional, Goodman, Anna L., additional, Jackson, Bethany, additional, Jenkin, Daniel, additional, Jones, Mathew, additional, Longet, Stephanie, additional, Makinson, Rebecca, additional, Marchevsky, Natalie G., additional, Mathew, Moncy, additional, Mazzella, Andrea, additional, Mujadidi, Yama F., additional, Parolini, Lucia, additional, Petersen, Claire, additional, Plested, Emma, additional, Pollock, Katrina M., additional, Rajeswaran, Thurkka, additional, Ramasamy, Maheshi N., additional, Rhead, Sarah, additional, Robinson, Hannah, additional, Robinson, Nicola, additional, Sanders, Helen, additional, Serrano, Sonia, additional, Stockmann, Helen, additional, Tipton, Tom, additional, Waters, Anele, additional, Zacharopoulou, Panagiota, additional, Barnes, Eleanor, additional, Dunachie, Susanna, additional, Goulder, Philip, additional, Klenerman, Paul, additional, Screaton, Gavin R., additional, Winston, Alan, additional, Hill, Adrian V. S., additional, Gilbert, Sarah C., additional, Carroll, Miles, additional, Pollard, Andrew J, additional, Fidler, Sarah, additional, Fox, Julie, additional, Lambe, Teresa, additional, and Frater, John, additional

Published
2021
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7. A gene locus that controls expression of ACE2 in virus infection

Author

Ansari, M. Azim, Marchi, Emanuele, Ramamurthy, Narayan, Aschenbrenner, Dominik, Hackstein, Carl-Philipp, Bowden, Rory, Sharma, Eshita, Pedergnana, Vincent, Venkateswaran, Suresh, Kugathasan, Subra, Mo, Angela, Gibson, Greg, McLauchlan, John, Barnes, Eleanor, Baillie, John Kenneth, Teichmann, Sarah, Mentzer, Alex, Todd, John, Knight, Julian, Uhlig, Holm, and Klenerman, Paul

Subjects
hormones, hormone substitutes, and hormone antagonists
Abstract

The SARS-CoV-2 pandemic has resulted in widespread morbidity and mortality globally, but with widely variable outcomes. The development of severe disease and mortality is higher in older individuals, males and those with other co-morbidities, and may vary across ethnic groups. However, so far, no host genetic factor has been clearly associated with susceptibility and development of severe disease. To understand the impact of host genetics on expression of ACE2 (SARS-CoV-2 receptor) during RNA virus infection we performed a GWAS for ACE2 expression in HCV-infected liver tissue from 195 individuals. We discovered that polymorphisms in the host IFNL region which control expression of IFNL3 and IFNL4 modulate ACE2 expression. ACE2 expression was regulated additionally by age, with a subsidiary effect of co-morbidity. The IFNL locus controlled expression of a gene network incorporating many well-known interferon-stimulated genes which anti-correlated with ACE2 transcript levels. The same anti-correlation was found in the gastrointestinal tract, a site of SARS-CoV-2 replication where inflammation driven interferon-stimulated genes are negatively correlated with ACE2 expression. The interferon dependent regulation of ACE2 was identified in a murine model of SARS-CoV-1 suggesting conserved regulation of ACE2 across species. Polymorphisms in the IFNL region, as well as age, may impact not only on classical antiviral responses but also on ACE2 with potential consequences for clinical outcomes in distinct ethnic groups and with implications for therapeutic interventions.

Published
2020
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11. Endemic hepatitis B virus (HBV) among hospital in-patients in Bangladesh, including evidence of occult infection

Author

Chowdhury, Fazle Rabbi, primary, McNaughton, Anna L, additional, Amin, Mohammad Robed, additional, Barai, Lovely, additional, Saha, Mili Rani, additional, Rahman, Tanjila, additional, Das, Bikash Chandra, additional, Hasan, M Rokibul, additional, Shahidul Islam, K M, additional, Faiz, M A, additional, Al-Mahtab, Mamun, additional, Mokaya, Jolynne, additional, Kronsteiner, Barbara, additional, Jeffery, Katie, additional, Andersson, Monique I, additional, de Cesare, Mariateresa, additional, Ansari, M Azim, additional, Dunachie, Susanna, additional, and Matthews, Philippa C, additional

Published
2020
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13. Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection

Author

Goh, Cyndi, primary, Golubchik, Tanya, additional, Ansari, M Azim, additional, de Cesare, Mariateresa, additional, Trebes, Amy, additional, Elliott, Ivo, additional, Bonsall, David, additional, Piazza, Paolo, additional, Brown, Anthony, additional, Slawinski, Hubert, additional, Martin, Natalie, additional, Defres, Sylviane, additional, Griffiths, Mike J, additional, Bray, James E, additional, Maiden, Martin C, additional, Hutton, Paula, additional, Hinds, Charles J, additional, Solomon, Tom, additional, Barnes, Ellie, additional, Pollard, Andrew J, additional, Sadarangani, Manish, additional, Knight, Julian C, additional, and Bowden, Rory, additional

Published
2019
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15. Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

Author

Downs, Louise, primary, Smith, David, additional, Lumley, Sheila F, additional, Patel, Meha, additional, McNaughton, Anna L, additional, Mokaya, Jolynne, additional, Ansari, M Azim, additional, Salih, Hizni, additional, Várnai, Kinga A, additional, Freeman, Oliver, additional, Cripps, Sarah, additional, Phillips, Jane, additional, Collier, Jane, additional, Woods, Kerrie, additional, Channon, Keith, additional, Davies, Jim, additional, Barnes, Eleanor, additional, Jeffery, Katie, additional, and Matthews, Philippa C, additional

Published
2018
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16. Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV)

Author

McNaughton, Anna L, primary, Roberts, Hannah E, additional, Bonsall, David, additional, de Cesare, Mariateresa, additional, Mokaya, Jolynne, additional, Lumley, Sheila F, additional, Golubchik, Tanya, additional, Piazza, Paolo, additional, Martin, Jacqueline B, additional, de Lara, Catherine, additional, Brown, Anthony, additional, Ansari, M Azim, additional, Bowden, Rory, additional, Barnes, Eleanor, additional, and Matthews, Philippa C, additional

Published
2018
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17. A comprehensive genomics solution for HIV surveillance and clinical monitoring in a global health setting

Author

Bonsall, David, primary, Golubchik, Tanya, additional, Cesare, Mariateresa de, additional, Limbada, Mohammed, additional, Kosloff, Barry, additional, MacIntyre-Cockett, George, additional, Hall, Matthew, additional, Wymant, Chris, additional, Ansari, M Azim, additional, Abeler-Dörner, Lucie, additional, Schaap, Ab, additional, Brown, Anthony, additional, Barnes, Eleanor, additional, Piwowar-Manning, Estelle, additional, Wilson, Ethan, additional, Emel, Lynda, additional, Hayes, Richard, additional, Fidler, Sarah, additional, Ayles, Helen, additional, Bowden, Rory, additional, and Fraser, Christophe, additional

Published
2018
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18. HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

Author

McNaughton, Anna L, primary, Lourenço, José, additional, Hattingh, Louise, additional, Adland, Emily, additional, Daniels, Samantha, additional, Zyl, Anriette Van, additional, Akiror, Connie S, additional, Wareing, Susan, additional, Jeffery, Katie, additional, Ansari, M Azim, additional, Klenerman, Paul, additional, Goulder, Philip J R, additional, Gupta, Sunetra, additional, Jooste, Pieter, additional, and Matthews, Philippa C, additional

Published
2017
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