1. Late (> 5 years) regional lymph node metastasis of oral squamous cell carcinoma (SCC), proven by p53 mutation analysis
- Author
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Robert J.J. van Es, J. Alain Kummer, Jan Willem M. Hoekstra, and University of Groningen
- Subjects
Male ,squamous cell carcinoma ,Pathology ,medicine.medical_specialty ,medicine.medical_treatment ,P53 Mutation ,Metastasis ,Diagnosis, Differential ,Cytosine ,IFN-beta-1a ,second primary tumour ,Carcinoma ,Medicine ,Humans ,Point Mutation ,Basal cell carcinoma ,HEAD ,Lymph node ,Mouth Floor ,p53 mutation analysis ,business.industry ,Cancer ,Neck dissection ,Neoplasms, Second Primary ,MULTIPLE-SCLEROSIS ,Middle Aged ,lymph node ,medicine.disease ,GENE ,medicine.anatomical_structure ,Otorhinolaryngology ,Epidermoid carcinoma ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Neck Dissection ,Surgery ,Mouth Neoplasms ,Oral Surgery ,Tumor Suppressor Protein p53 ,business ,Thymine ,late metastasis ,Follow-Up Studies - Abstract
Background: A late (>5 years) neck nodal metastasis of oral cancer, poses a problem to the clinician: is it a late metastasis or a metastasis of a (unknown) second primary tumour? Methods: A 50-year-old male was seen with a contralateral lymph node metastasis, 51/2 years after treatment of a pT2N1M0 carcinoma in the floor of the mouth. Both the late metastasis and the original tumour specimen were analysed for p53 mutations. Results: Both specimens showed an identical p53 mutation, thereby confirming the lymph node to be a late metastasis. Conclusions: A lymph node metastasis can occur more than 5 years after treatment of an oral squamous cell carcinoma. p53 mutation analysis is of help to discriminate it from a second primary tumour. (C) 2008 European Association for Cranio-Maxillofacial Surgery.
- Published
- 2008
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