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Based on the capillary bundle model, combined with the relationship between the boundary layer thickness and the pressure gradient, a modified low-velocity nonlinear flow model for offshore low permeability reservoir was established. By using the fluid-solid coupling model and the 3D fractured well black oil model based on embedded mesh, the stability of numerical simulation was compared with that of traditional and our proposed low-velocity nonlinear flow model. Finally, the well spacing of five points well pattern in offshore low permeability reservoir was optimized. The results show that compared with previous studies, our proposed nonlinear flow model is more reasonable. The accuracy of fitting with experimental data is higher. Compared with the traditional flow model, our proposed low-velocity nonlinear flow model can reduce the number of nonlinear iterations by 85. 7% in a numerical simulation model of depletion production. At the same time, in an injection-production numerical model of two fracturing wells, our proposed nonlinear flow model makes it stable convergent from non-convergent. With the increase of well spacing, the cumulative oil production of well group increases first and then decreases. There is an optimal well spacing. In addition, the optimal well spacing increases with increasing matrix permeability. This method provides an efficient tool for accurately optimizing well pattern parameters of offshore low permeability reservoir. [ABSTRACT FROM AUTHOR]