11 results on '"Lin YX"'
Search Results
2. Neutrophil to lymphocyte ratio is a prognosis factor for post-operative pneumonia in aneurysmal subarachnoid hemorrhage patients.
- Author
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Chen Y, Lian BQ, Peng L, Ding CY, Lin YX, Yu LH, Wang DL, and Kang DZ
- Subjects
- Humans, Lymphocytes, Neutrophils, Prognosis, Treatment Outcome, Pneumonia etiology, Subarachnoid Hemorrhage
- Abstract
Background: Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm (post-operative pneumonia [POP]) in patients with aneurysmal subarachnoid hemorrhage (aSAH) have been studied, the predictive model of POP after aSAH has still not been well established. Thus, the aim of this study was to assess the feasibility of using admission neutrophil to lymphocyte ratio (NLR) to predict the occurrence of POP in aSAH patients., Methods: We evaluated 711 aSAH patients who were enrolled in a prospective observational study and collected admission blood cell counts data. We analyzed available demographics and baseline variables for these patients and analyzed the correlation of these factors with POP using Cox regression. After screening out the prognosis-related factors, the predictive value of these factors for POP was further assessed., Results: POP occurred in 219 patients (30.4%) in this cohort. Patients with POP had significantly higher NLR than those without (14.11 ± 8.90 vs. 8.80 ± 5.82, P < 0.001). Multivariate analysis revealed that NLR remained a significant factor independently associated with POP following aSAH after adjusting for possible confounding factors, including the age, World Federation of Neurosurgical Societies (WFNS) grade, endovascular treatment, and ventilator use. And the predictive value of NLR was significantly increased after WFNS grade was combined with NLR (NLR vs. WFNS grade × NLR, P = 0.011)., Conclusions: Regardless of good or poor WNFS grade, patients having NLR >10 had significantly worse POP survival rate than patients having NLR ≤10. NLR at admission might be helpful as a predictor of POP in aSAH patients., (Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.)
- Published
- 2020
- Full Text
- View/download PDF
3. Systemic inflammatory response index improves the prediction of postoperative pneumonia following meningioma resection.
- Author
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Chen Y, Lin YX, Pang Y, Zhang JH, Gu JJ, Zhang GQ, Yu LH, Lin ZY, Kang DZ, Ding CY, and Fang WH
- Subjects
- Humans, Neurosurgical Procedures, Postoperative Complications, Retrospective Studies, Systemic Inflammatory Response Syndrome, Meningeal Neoplasms surgery, Meningioma surgery, Pneumonia diagnosis, Pneumonia etiology
- Published
- 2020
- Full Text
- View/download PDF
4. Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients.
- Author
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Ling Y, Xu SB, Lin YX, Tian D, Zhu ZQ, Dai FH, Wu F, Song ZG, Huang W, Chen J, Hu BJ, Wang S, Mao EQ, Zhu L, Zhang WH, and Lu HZ
- Subjects
- Adult, Aged, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Coronavirus Infections diagnosis, Coronavirus Infections rehabilitation, Female, Humans, Male, Middle Aged, Pandemics, Pneumonia, Viral rehabilitation, Real-Time Polymerase Chain Reaction, Retrospective Studies, SARS-CoV-2, Betacoronavirus genetics, Coronavirus Infections genetics, Pneumonia, Viral genetics, RNA, Viral genetics
- Abstract
Background: A patient's infectivity is determined by the presence of the virus in different body fluids, secretions, and excreta. The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease (COVID-19) remain unclear. This study analyzed the clearance time and factors influencing 2019 novel coronavirus (2019-nCoV) RNA in different samples from patients with COVID-19, providing further evidence to improve the management of patients during convalescence., Methods: The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20, 2020 to February 10, 2020 were collected retrospectively. The reverse transcription polymerase chain reaction (RT-PCR) results for patients' oropharyngeal swab, stool, urine, and serum samples were collected and analyzed. Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive (minimum 24 h sampling interval) negative RT-PCR results for viral RNA from oropharyngeal swabs. The effects of cluster of differentiation 4 (CD4)+ T lymphocytes, inflammatory indicators, and glucocorticoid treatment on viral nucleic acid clearance were analyzed., Results: In the 292 confirmed cases, 66 patients recovered after treatment and were included in our study. In total, 28 (42.4%) women and 38 men (57.6%) with a median age of 44.0 (34.0-62.0) years were analyzed. After in-hospital treatment, patients' inflammatory indicators decreased with improved clinical condition. The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5 (6.0-11.0) days. By February 10, 2020, 11 convalescent patients (16.7%) still tested positive for viral RNA from stool specimens and the other 55 patients' stool specimens were negative for 2019-nCoV following a median duration of 11.0 (9.0-16.0) days after symptom onset. Among these 55 patients, 43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs, with a median delay of 2.0 (1.0-4.0) days. Results for only four (6.9%) urine samples were positive for viral nucleic acid out of 58 cases; viral RNA was still present in three patients' urine specimens after throat swabs were negative. Using a multiple linear regression model (F = 2.669, P = 0.044, and adjusted R = 0.122), the analysis showed that the CD4+ T lymphocyte count may help predict the duration of viral RNA detection in patients' stools (t = -2.699, P = 0.010). The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (15 days vs. 8.0 days, respectively; t = 2.550, P = 0.013) and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group (20 days vs. 11 days, respectively; t = 4.631, P < 0.001). There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results (P > 0.05)., Conclusions: In brief, as the clearance of viral RNA in patients' stools was delayed compared to that in oropharyngeal swabs, it is important to identify viral RNA in feces during convalescence. Because of the delayed clearance of viral RNA in the glucocorticoid treatment group, glucocorticoids are not recommended in the treatment of COVID-19, especially for mild disease. The duration of RNA detection may relate to host cell immunity.
- Published
- 2020
- Full Text
- View/download PDF
5. Charcot Elbow Joint as the Initial Symptom in Chiari Malformation with Syringomyelia.
- Author
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Zhou Y, Zhu L, Lin YX, and Cheng HL
- Subjects
- Adult, Female, Humans, Arnold-Chiari Malformation diagnosis, Elbow Joint pathology, Syringomyelia diagnosis
- Published
- 2015
- Full Text
- View/download PDF
6. Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis.
- Author
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Zhou Y, Zhu L, Cheng HL, and Lin YX
- Subjects
- Adult, Female, Humans, Magnetic Resonance Imaging, Methylprednisolone therapeutic use, Neuromyelitis Optica drug therapy, Neuromyelitis Optica etiology, Spondylosis complications, Spondylosis drug therapy, Neuromyelitis Optica diagnosis, Spondylosis diagnosis
- Published
- 2015
- Full Text
- View/download PDF
7. The experts consensus for patient management of neurosurgical critical care unit in China (2015).
- Author
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Zhao JZ, Zhou DB, Zhou LF, Wang RZ, Zhang JN, Wang S, Li XG, Hua-Feng, Liu J, Jiang J, Zhang S, Zhang JT, Zhang JM, Lijun-Hou, Hong T, Yuan XR, Gao GD, Kang DZ, You C, ShengdeBao, Qi ST, Zhao SG, Zhao YL, Hu J, Cui LY, Peng B, Liu DW, Guo SB, Lin YX, Sun SZ, Gao L, Jiang RC, Shi GZ, Chai WZ, Wang N, Zhao YL, and Wei JJ
- Subjects
- China, Consensus, Disease Management, Humans, Intensive Care Units, Critical Care standards, Neurosurgery standards
- Published
- 2015
- Full Text
- View/download PDF
8. Predictive validity of BODE index for anxious and depressive symptoms in patients with chronic obstructive pulmonary disease.
- Author
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An L, Lin YX, Yang T, Zhang H, Jiao X, Zhang S, Chang XH, Wang ZM, and Wang C
- Subjects
- Cross-Sectional Studies, Humans, Multivariate Analysis, Prospective Studies, Anxiety diagnosis, Depression diagnosis, Pulmonary Disease, Chronic Obstructive pathology, Pulmonary Disease, Chronic Obstructive psychology
- Abstract
Background: Anxiety and depression are two of the commonest and most modifiable comorbidities of chronic obstructive pulmonary disease (COPD) and have an independent effect on health and prognosis. FEV1% has been shown to be a poor predictor of anxiety and depression. The body mass index, degree of airflow obstruction, dyspnea, and exercise capacity (BODE) index is a multidimensional assessment system which may predict health outcome in COPD patients. The purpose of this study was to investigate the predictive validity of the BODE index for anxious and depressive symptoms in COPD patients., Methods: This was a multicenter prospective cross-sectional study in 256 patients with stable COPD. Anxious and depressive symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). The relationships between anxiety, depression and potential predictors (including the BODE index) were analyzed by a binary Logistic regression model., Results: Subjects who were anxious and depressive walked a shorter six-minute walking distance (6MWD), had more dyspnea, a higher BODE index, and lower health-related quality of life (P < 0.01). Anxiety and depression score was significantly correlated with BODE index, respectively (r = 0.335, P < 0.001; r = 0.306, P < 0.001). The prevalence of anxiety and depression increased with BODE stage increasing (P < 0.05). On the basis of binary Logistic regression, the BODE index was a good and independent predictor of anxiety and depression because it comprised dyspnea and 6MWD, which were shown to be the main determinants., Conclusions: The predictive validity of the BODE index for anxiety and depression was demonstrated. We propose that the BODE index should be included in assessment of COPD severity.
- Published
- 2010
9. The cross-sectional and longitudinal association of the BODE index with quality of life in patients with chronic obstructive pulmonary disease.
- Author
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Lin YX, Xu WN, Liang LR, Pang BS, Nie XH, Zhang J, Wang H, Liu YX, Wang DQ, Xu ZY, Wang HW, Zhang HS, He ZY, Yang T, and Wang C
- Subjects
- Aged, Body Mass Index, Cross-Sectional Studies, Dyspnea pathology, Dyspnea physiopathology, Exercise Tolerance physiology, Female, Humans, Linear Models, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Respiratory Function Tests, Smoking, Surveys and Questionnaires, Pulmonary Disease, Chronic Obstructive pathology, Pulmonary Disease, Chronic Obstructive physiopathology, Quality of Life
- Abstract
Background: The body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index was shown at predicting the risk of death, exacerbation and disease severity among patients with COPD, but few studies verified relationship between BODE index and health related quality of life (HRQoL) among Chinese COPD patients. The objective of this study was to evaluate the relationship between BODE index and HRQoL in cross-sectional and longitudinal association analyses., Methods: A multi-center prospective cohort study was initially conducted in 491 stable COPD patients in Beijing, China. Health status (HRQoL) was assessed by St. George's Respiratory Questionnaire (SGRQ); the BODE index was calculated for each patient; dyspnea was assessed using the 5-grade Medical Research Council dyspnea scale. Other measurements included socio-demographic, body mass index (BMI), lung function test and 6-minute-walk test (6MWT). Patients were then followed monthly for 12 months., Results: Only 450 patients completed the 1-year follow up and were enrolled in our present analyses. Mean age was (65.2 +/- 10.6) years, men 309 (68.7%). The BODE index was categorized into 4 subgroups: 0 - 2, 3 - 4, 5 - 6 and 7 - 10. At baseline BODE index was gradually increased with baseline total SGRQ and SGRQ subscales (P trend < 0.001). For individual components of BODE index, with the decrease of airflow limitation, and 6MWD, and with the increase of Medical Research Council (MRC) dyspnea grade, total SGRQ and SGRQ subscales were increased correspondingly, P trend < 0.05, respectively. Similar association patterns were found between baseline BODE index and its individual components and mean SGRQ scores at the end of 1-year follow up. By multiple linear regression analyses, baseline BODE index was not only significantly associated with SGRQ score at baseline but also with SGRQ score at the end of 1-year follow up after adjustment for age, male, current smoking, betas being 0.434 and 0.378, respectively., Conclusions: BODE index is associated with SGRQ score cross-sectionally and longitudinally among stable COPD patients. BODE index might have potential to be used as a sensitive tool to assess the status of quality of life and to monitor disease progression among stable COPD patients.
- Published
- 2009
10. Current status of adult-to-adult living donor liver transplantation: surgical techniques and innovations.
- Author
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Yan LN, Wu H, Chen ZY, and Lin YX
- Subjects
- Humans, Liver blood supply, Survival Analysis, Tissue and Organ Harvesting methods, Liver Transplantation methods, Living Donors
- Published
- 2009
11. Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms.
- Author
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Kang DZ, Wu ZY, Lan Q, Yu LH, Lin ZY, Wang CY, and Lin YX
- Subjects
- Adolescent, Adult, Aged, Brain Stem physiopathology, Female, Humans, Intracranial Aneurysm physiopathology, Male, Middle Aged, Sensitivity and Specificity, Evoked Potentials, Auditory, Brain Stem, Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Intracranial Aneurysm surgery, Microsurgery, Monitoring, Intraoperative
- Abstract
Background: Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combined monitoring of transcranial electrical stimulation motor evoked potentials (TES-MEPs), somatosensory evoked potentials (SSEPs) and brainstem auditory evoked potentials (BAEPs) was attempted in microsurgery for lesions adjacent to the brainstem and intracranial aneurysms., Methods: Monitoring of combined TES-MEPs with SSEPs was attempted in 68 consecutive patients with lesions adjacent to the brainstem as well as intracranial aneurysms. Among them, 31 patients (31 operations, 28 of posterior cranial fossa tumors, 3 of posterior circulation aneurysms) were also subjected to monitoring of BAEPs. The correlation of monitoring results and clinical outcome was studied prospectively., Results: Combined monitoring of evoked potentials (EPs) was done in 64 (94.1%) of the 68 patients. MEPs monitoring was impossible for 4 patients (5.9%). No complication was observed during the combined monitoring in all the patients. In 45 (66.2%) of the 68 patients, EPs were stable, and they were neurologically intact. Motor dysfunction was detected by MEPs in 8 patients, SSEPs in 5, and BAEPs in 4, respectively., Conclusions: A close relationship exists between postoperative motor function and the results of TES-MEPs monitoring. TES-MEPs are superior to SSEPs and BAEPs in detecting motor dysfunction, but combined EPs serve as a safe, effective and invasive method for intraoperative monitoring of the function of the motor nervous system. Monitoring of combined EPs during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms may detect potentially hazardous maneuvers and improve the safety of subsequent procedures.
- Published
- 2007
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