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Objective To discuss the association between the different cut-off point of FRAX and BMD, and the clinical value in Wuxi region. Methods We collected the medical examination of hospital staff, we measured the BMD through DXA, simultaneously we evaluated the 10-year risk of bone fragility by FRAX (Fracture Risk Assessment Tool). The gold standard is BMD, We explored age, sex, height, weight to affect the results of FRAX by multiple linear regression analysis. Results Compared with DXA, the cut-off point of America, the Sensitivity is 3. 51%, the Specific is 99. 79%, the positive predictive value is 66. 67%, the negative predictive value is 89. 95%. Then England, the Sensitivity is 3. 51%, the Specific is 98. 58%, the positive predictive value is 22. 22%, the negative predictive value is 89. 83%; Compared with Japan, the Sensitivity is 8. 77%, the Specific is98. 38%, the positive predictive value is 38. 46%, the negative predictive value is 90. 32%. then Urumqi the Sensitivity is 5. 26%, the Specific 97. 97%, the positive predictive value is 23. 08%, the negative predictive value is 89. 94%. the greatest impact on the FRAX results is age and femoral neck T-score. Conclusion The clinical value of the different intervention cut-off point of FRAX in Wuxi region is meaningless, we should establish an appropriate cut-off point of Local region. [ABSTRACT FROM AUTHOR]