Search

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Toll-like receptor 4 is an important innate immune pattern recognition receptor. It activates NF-κB signaling pathway by triggering myeloid differentiation factor 88-dependent pathway after identifying damage related molecular patterns and pathogen related molecular patterns, and lead to the secretion of inflammatory mediators and cytokines. It triggers innate immune response, and playing a role in the occurrence of synovitis in knee osteoarthritis. Study the role of TLR4/MyD88 signaling pathway in synovitis of knee osteoarthritis, can clarify the pathogenesis about synovitis of knee osteoarthritis and provide theoretical basis and reference for the diagnosis and treatment on synovitis of knee osteoarthritis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Knee osteoarthritis (OA) is a common chronic progressive joint disease with pain and loss of joint function. The etiology of this disease is complex and its pathogenesis has not been fully elucidated. In recent years, with the deepening of research on the relationship between matrix metalloproteinases and OA, it has been found that matrix metalloproteinases play an important role in the occurrence and development of OA by affecting the important pathological process of articular cartilage destruction, A large number of studies have shown that traditional Chinese medicine (TCM) interferes with the expression of matrix metalloproteinases in patients with knee OA and inhibits the degradation of extracellular chondrocyte matrix, thus reducing the clinical symptoms and delaying the pathological process of knee OA. This paper reviews the research progress of TCM intervention on matris metalloproteinase expression in the treatment of knee OA, in order to provide reference and basis for the application of TCM in the prevention and treatment of knee OA. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To discuss the expression of high mobility group box 1 protein (HMGB1) and bone morphogenetic protein 2 (BMP2) in rat models of calvarial bone defect. Methods Skull bone defect model was established in 300 Sprague-Dawley rats and the rats were randomly divided into control group and treatment group, with 150 rats in each group. Each group was divided into 3 groups of 7d, 14d and 28d, with 50 rats in each group. The rats in the treatment group were given 42 mg/kg of natural musk, and the control group was given the same amount of normal saline, once per day. The expression of HMGB1 and BMP2 was detected by Western blotting at 7d, 14d and 28d. Results The expression of HMGB1 and BMP2 in the treatment group reached the peak on the 7th day (P<0.05), decreased on the 14th day and was the lowest on the 28th day. Compared with the control group, the expression of HMGB1 and BMP2 on the 7th day was significantly different (P<0.05). In the treatment group, the expression of HMGB1 on the 7th and 14th day was significantly higher than that of the 28th day (P<0.05). Conclusion Musk increased the expression of HMGB1 and BMP2 in rats, which may be one of the causes of skull bone defect healing. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the clinical value of serum 25(OH) D and bone turnover markers in the prediction of osteoporotic hip fractures in the elderly. Methods A total of 330 cases with hip fractures and 331 cases without fractures from May 2015 to April 2016 were retrospectively analyzed and divided into two groups according to the occurrence of hip fractures. The general clinical information was collected,including age,sex,height,weight,body mass index,and the history of smoking and drinking. Serum levels of 25 (OH) D,PINP,OC,CTX,and PTH were measured and analyzed. Results Patients with hip fractures had significantly lower level of serum 25 (OH) D,higher levels of serum CTX-1,P1 NP,and OC than those without hip fractures (P<0.05). The Pearson correlation analysis showed that serum 25(OH) D was negatively correlated with PTH,P1 NP,OC,and CTX (P<0.05). The multiple logistic regression analysis showed that age,serum 25 (OH) D,and CTX-1 were independent risk factors of hip fractures in senile patients (P<0.05).The receiver operating curves showed that age,serum 25(OH)D,and CTX had AUC values of 0.819,0.802,and 0.666,respectively,which were of significance in predicting hip fractures. Conclusion The older age,vitamin D deficiency,and elevated serum CTX levels suggest an increased risk of hip fracture in elderly patients,who should be aware of hip fractures and take preventive measures in advance [ABSTRACT FROM AUTHOR]

Through screening and analyzing of relevant literatures on the methods and characteristics of knee synovitis treatment, we classified the efficacy of traditional Chinese medicine (TCM) external treatment on knee synovitis and other commonly used therapies. There are many combinations of TCM external treatment with other treatment methods, but uniformed clinical treatment guidelines are yet to be established. TCM external treatment in combination with other therapy methods have significant effects on the treatment of knee synovitis, and their clinical application is worthy of further promotion. [ABSTRACT FROM AUTHOR]

Objective To identify the related factors of osteoporosis in breast cancer women 1-year after the surgery. Methods Forty-one breast cancer patients 1-year after surgery aged from 53 to 75 years old with osteoporosis were selected. Fifty-six breast cancer patients 1-year after surgery aged from 46 to 64 years old with normal bone mineral density (BMD) were selected in the control group. BMD of the lumbar spine and the left femoral neck was detected using dual-energy X-ray absorptiometry (GE, USA). The correlation analysis among age, BMI, reproductive history, postmenopausal time, ER, PR, HER-2, and BMD was performed. Results There was significant difference in age, BMI, and postmenopausal time between OP group and NOP group (P<0.05). However, there was no difference in ER, PR, HER-2, and reproductive history between the two groups (P>0.05). Correlation analysis indicated that BMD was positively correlated with BMI, but was negatively correlated with age and postmenopausal time. Conclusion The prevalence of osteoporosis in women with breast cancer is high. The main influential factors are age, BMI, and postmenopausal time. [ABSTRACT FROM AUTHOR]

To analyze the effect of stem cell factor ( SCF) and monocyte chemotaxis protein 1 ( MCP-1) on the skull bone defect and the effect of musk on the expression of the two factors in the rat model． Methods The skull bone defect model established with drilling． The model rats were randomly divided into treatment group and model group，and then the treatment group and model group were randomly divided into three groups． Ｒats in the treatment group were gavaged with musk，and rats in the model group were administrated with saline，respectively． After 7d，14d，and 28d of the intervention，the expression of SCF was detected with enzyme-linked immunosorbent sorbent assay ( ELISA) ，and MCP-1 mＲNA expression was detected with real-time fluorescence quantitative PCＲ． Ｒesults Compared with the model group，SCF expression was the lowest in the treatment group on the 14th day，with no significant difference． SCF expression was higher at 7 days and 28 days than that at the 14 day，and the different was statistically significant between model group and treatment group ( P = 0. 0002，0. 0025 ) ． The increase of SCF expression was more significantly on the 7th day． MCP-1 mＲNA expression was the highest in the treatment group on the 7th day， and it was significantly different compared with the model group ( P ＜ 0. 05) ． The expression continued to decrease on the 14th and 28th day，and it was not statistically significant compared with the model group ( P = 0. 0633，0. 1597) ． Conclusion SCF and MCP-1 play an important role in bone defect healing． Musk increases the serum SCF expression and MCP-1 mＲNA expression in the skull bone defect tissues，indirectly indicating that the healing of bone defects may be associated with the increase of SCF and MCP- 1 mＲNA expression． Musk plays an important role in accelerating the healing of bone defects in the microenvironment． [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of musk on the levels of stromal cell-derived factor 1 (SDF-1) and hepatocyte growth factor (HGF) in the rat calvarial bone defect model． Methods 150 male and female SD rats were used to establish the model of skull bone defect with dental drill． Model animals were randomly divided into the medicine group and model group． The two groups were further divided into 3 groups，with 50 rats in each group． Ｒats in the treatment group received musk，and rats in the model group were gavaged with normal saline． Serum SDF-1 and HGF were determined in each group at 7 d，14 d，and 28 d with enzyme-linked immunosorbent assay (ELISA) ． The resulting OD value was analyzed using a SPSS 17. 0 software． Ｒesults Comparing to the model group，SDF-1 in the treatment group increased on 7 d，and the difference was statistically significant (P = 0. 0008) ． HGF increased on 7 d and 14 d (P = 0. 0234，P = 0. 0158) ，and the increase was the highest on 7 d． Conclusion Musk promotes the healing of rat cranial bone defect area，and this healing mechanism may be associated with the increase of serum SDF-1 and HGF expression． [ABSTRACT FROM AUTHOR]

Knee joint adhesion and rigid are serious complications following knee or knee joint peripheral trauma or surgery due to prolonged joint immobilization, lack of exercise, incorrect functional exercise or improper internal fixation. It is a common and frequently-occurring disease in clinic, which can seriously affect the patient's daily life and work, cause pain, and impact the patients' families and society. Thus, in recent years, research on the treatment of this disease received great attention internationally, and great progress had been made. Through the unremitting efforts of the many clinical workers, on the basis of integrating traditional treatment methods, a number of more effective and safe treatment methods were developed. The authors of this paper summarized the progress in traditional Chinese medicine and Western medicine on the treatment of adhesive knee joint stiffness in recent years, with the aim to guide more clinical workers to use these methods flexibly, to minimize the suffering of patients, and to reduce the burden of the society. [ABSTRACT FROM AUTHOR]

With the increase of aging population in China, the incidence of primary osteoporosis is increasing, which not only increases the expense of medical care of the country and the society, but also increases the burden of people. How to prevent, to relieve,or to reverse the progress of osteoporosis has always been a hot spot in biomedical research. Therefore, it is important to understand the pathogenesis and the development of osteoporosis in order to provide a theoretical support for the development of drugs. In recent years, it has been reported that OPG /RANK /RANKL signaling pathway is obviously correlated with the occurrence and development of osteoporosis. This article reviews the current situation of this cellular pathway and its effect, in order to help future research in this signaling pathway and the prevention and treatment of osteoporosis. [ABSTRACT FROM AUTHOR]