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Objective To explore the potential dual-effect components and mechanism of Cistanches Herba in the treatment of osteoporosis with chronic kidney disease by network pharmacology and molecular docking technology. Methods Through multiple databases and literature searches, the intersection of the active ingredients of Cistanche and their corresponding targets with Chronic Kidney Disease（CKD） and Osteoporosis（OP） related disease targets was screened out, and then, construct a PPI network in the STRING database, screen the core targets with the CytoHubba plug-in, and perform GO ontology and KEGG pathway enrichment analysis in the DAVID database. After constructing the active ingredient-core target-signaling pathway network in Cytoscape, the key components, key targets and Key signal pathways, and finally molecular docking verification in AutoDockTools. ResultsObtained 3 key components of Cistanche for the treatment of CKD-OP（quercetin, β-sitosterol, salidroside）, 6 key targets（AKT1, TNF, MAPK1, JUN, RELA and PTGS2）, 3 key signal pathways（TNF, NF-κB and Oxytocin signaling pathways）. ConclusionThe preliminary discovery of the potential molecular pharmacological mechanism of Cistanche cistanche in the specific treatment of CKD-OP through "multi-component-multi-target-multi-pathway" provides a theoretical basis and ideas for the modernization of traditional Chinese medicine and the treatment of CKD-OP. [ABSTRACT FROM AUTHOR]